Chen C H, Gong M, Yi Q T, Guo J H
Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Huinan Town, Pudong, Shanghai, China.
Genet Mol Res. 2015 Oct 27;14(4):13370-4. doi: 10.4238/2015.October.26.34.
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. A total of 212 consecutive primary prostate cancer patients and 236 control subjects were recruited between May 2012 and May 2014. The IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) met the Hardy-Weinberg equilibrium in the controls. Unconditional logistic regression analyses showed that the GG genotype of IL-6-572C>G (rs1800796) was associated with an elevated risk of prostate cancer compared with the CC genotype, and the OR (95%CI) for the GG genotype was 2.06 (1.11-3.87). In conclusion, we suggest that the IL-6-572C>G (rs1800796) gene polymorphism influences the development of prostate cancer.
我们研究了两种功能性多态性，即白细胞介素-6（IL-6）-174G>C（rs1800795）和IL-6-572C>G（rs1800796）在前列腺癌发生发展中的作用。在2012年5月至2014年5月期间，共招募了212例连续的原发性前列腺癌患者和236例对照者。通过聚合酶链反应-限制性片段长度多态性方法评估IL-6-174G>C（rs1800795）和IL-6-572C>G（rs1800796）多态性。IL-6-174G>C（rs1800795）和IL-6-572C>G（rs1800796）的基因型分布在对照组中符合哈迪-温伯格平衡。无条件逻辑回归分析显示，与CC基因型相比，IL-6-572C>G（rs1800796）的GG基因型与前列腺癌风险升高相关，GG基因型的比值比（95%置信区间）为2.06（1.11 - 3.87）。总之，我们认为IL-6-572C>G（rs1800796）基因多态性影响前列腺癌的发生发展。
