孕期使用贯叶连翘及其妊娠结局。

Hypericum perforatum use during pregnancy and pregnancy outcome.

作者信息

Kolding Line, Pedersen Lars Henning, Henriksen Tine Brink, Olsen Jørn, Grzeskowiak Luke E

机构信息

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Aarhus University, Palle Juul-Jensens Blvd. 99, 8200, Aarhus N, Denmark.

Dept. Paediatrics (Intensiv Care Neonatology) and Perinatal Research Unit, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200, Aarhus N, Denmark.

出版信息

Reprod Toxicol. 2015 Dec;58:234-7. doi: 10.1016/j.reprotox.2015.10.003. Epub 2015 Nov 1.

DOI:10.1016/j.reprotox.2015.10.003

PMID:26536653

Abstract

Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated. Preterm birth did not differ across the groups. While the prevalence of malformations in the HP exposed group was slightly higher (8.1%) than observed in the control groups (3.3%; p=0.13), this was based on only three cases and was not of any specific pattern.

摘要

贯叶连翘（HP；也被称为圣约翰草）是治疗抑郁症最常用的草药疗法之一。本研究的目的是评估孕期使用贯叶连翘对妊娠结局的潜在副作用。利用丹麦国家出生队列（DNBC）的数据，我们调查了38例暴露于贯叶连翘的妊娠结局，并与90128名女性组成的对照组进行比较。研究了贯叶连翘的使用与孕周、早产、出生体重、畸形和阿氏评分之间的关联。各组之间早产情况没有差异。虽然暴露于贯叶连翘组的畸形发生率略高于对照组（分别为8.1%和3.3%；p = 0.13），但这仅基于3例病例，且没有任何特定模式。