Yüce Süleyman, Cüre Erkan, Çiçek Yüksel, Cumhur Cüre Medine, Yılmaz Arif, Kızılkaya Bayram
Department of Internal Medicine, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Turkey.
Department of Cardiology, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Turkey.
Turk Kardiyol Dern Ars. 2015 Oct;43(7):599-606. doi: 10.5543/tkda.2015.44457.
Gilbert's syndrome (GS) is an autosomal recessive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS.
The study included 58 GS patients (32 females, age; 27.12 ± 7.27 years, 26 males, age; 26.63 ± 5.84 years) admitted to the internal medicine clinic of the hospital. The control group included 58 healthy individuals (35 females [27.33 ± 8.06 years old, p=0.716] and 23 males [27.38 ± 6.91 years old, p=0.923]). PWV of both groups was measured from the right carotid and femoral arteries.
Mean age of the GS group was 26.03 ± 8.22 years, while that of the healthy group was 26.60 ± 5.84 years. The GS group's diastolic blood pressure and PWV were significantly lower than those of the control group: 67.76 ± 8.59 mmHg vs 71.72 ± 7.28 mmHg; p=0.008, and 5.63 ± 1.12 m/s vs 6.18 ± 1.22 m/s; p=0.014 respectively. The GS group's high density lipoprotein (HDL) level was significantly higher than that of the control group: 1.4 ± 0.3 mmol/L vs 1.2 ± 0.3 mmol/L, p=0.029.
This study found PWV among GS patients to be lower than that among non-smoking and aged-matched healthy controls.
吉尔伯特综合征（GS）是一种常染色体隐性疾病，其特征为间接胆红素（IB）升高。GS患者的动脉粥样硬化性心脏病发病率降低。本研究旨在探讨脉搏波速度（PWV）与GS存在之间的关系。
该研究纳入了58例入住医院内科门诊的GS患者（32例女性，年龄；27.12±7.27岁，26例男性，年龄；26.63±5.84岁）。对照组包括58名健康个体（35例女性[27.33±8.06岁，p=0.716]和23例男性[27.38±6.91岁，p=0.923]）。两组均从右颈动脉和股动脉测量PWV。
GS组的平均年龄为26.03±8.22岁，而健康组为26.60±5.84岁。GS组的舒张压和PWV显著低于对照组：分别为67.76±8.59 mmHg对71.72±7.28 mmHg；p=0.008，以及5.63±1.12 m/s对6.18±1.22 m/s；p=0.014。GS组的高密度脂蛋白（HDL）水平显著高于对照组：1.4±0.3 mmol/L对1.2±0.3 mmol/L，p=0.029。
本研究发现GS患者的PWV低于非吸烟且年龄匹配的健康对照组。
