• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

In vivo evaluation of Michaelis-Menten constants of hepatic drug-eliminating systems.

作者信息

Pang K S, Rowland M, Tozer T N

出版信息

Drug Metab Dispos. 1978 Mar-Apr;6(2):197-200.

PMID:26537
Abstract
摘要

相似文献

1
In vivo evaluation of Michaelis-Menten constants of hepatic drug-eliminating systems.肝药物消除系统米氏常数的体内评估
Drug Metab Dispos. 1978 Mar-Apr;6(2):197-200.
2
Clearance and biologic half-life as indices of intrinsic hepatic metabolism.清除率和生物半衰期作为肝脏内在代谢的指标。
J Pharmacol Exp Ther. 1974 Oct;191(1):17-24.
3
Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance.通过体外测量内在清除率预测肝脏提取率。
J Pharmacol Exp Ther. 1977 Feb;200(2):420-4.
4
Genetic factors in hepatic drug oxidation.肝脏药物氧化中的遗传因素。
Prog Liver Dis. 1976;5:246-58.
5
The area under the curve of metabolites for drugs and metabolites cleared by the liver and extrahepatic organs. Its dependence on the administration route of precursor drug.肝脏和肝外器官清除的药物及代谢物的代谢物曲线下面积。其对前体药物给药途径的依赖性。
Drug Metab Dispos. 1985 Jan-Feb;13(1):97-101.
6
Physiologic pharmacokinetic models: relevance, experience, and future trends.生理药代动力学模型：相关性、经验及未来趋势。
Drug Metab Rev. 1984;15(1-2):55-74. doi: 10.3109/03602538409015057.
7
[Changes in drug kinetics in liver diseases and their importance in rational pharmacotherapy].[肝脏疾病中药物动力学的变化及其在合理药物治疗中的重要性]
Pol Tyg Lek. 1977 Dec 26;32(52):2057-60.
8
First-pass effect: nonlinear concept comprising an explicit solution of integrated Michaelis-Menten equation.首过效应：非线性概念，包含米氏方程积分的显式解。
J Pharm Sci. 1981 Feb;70(2):195-8. doi: 10.1002/jps.2600700221.
9
Use of a programmable calculator to determine steady-state levels of drugs eliminated by parallel first-order and Michaelis-Menten kinetics.使用可编程计算器来确定通过平行一级动力学和米氏动力学消除的药物的稳态水平。
Am J Hosp Pharm. 1978 Sep;35(9):1075-7.
10
Influence of administration route and blood sampling site on the area under the curve. Assessment of gut wall, liver, and lung metabolism from a physiological model.
Drug Metab Dispos. 1983 Jan-Feb;11(1):62-6.

引用本文的文献

1
The potential of developing high hepatic clearance drugs via controlled release: Lessons from Kirchhoff's Laws.通过控制释放开发高肝清除药物的潜力：基尔霍夫定律的启示。
J Control Release. 2024 Sep;373:564-567. doi: 10.1016/j.jconrel.2024.07.040. Epub 2024 Jul 29.
2
Saturable kinetics of intravenous chlorothiazide in the rhesus monkey.恒河猴静脉注射氯噻嗪的饱和动力学
J Pharmacokinet Biopharm. 1981 Aug;9(4):461-76. doi: 10.1007/BF01060889.
3
On the identification of Michaelis-Menten elimination parameters from a single dose-response curve.
关于从单剂量反应曲线识别米氏消除参数
J Pharmacokinet Biopharm. 1984 Apr;12(2):193-221. doi: 10.1007/BF01059278.
4
Prediction of metabolic drug interactions involving beta-adrenoceptor blocking drugs.涉及β-肾上腺素能受体阻断药物的代谢性药物相互作用预测
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):3S-10S. doi: 10.1111/j.1365-2125.1984.tb02422.x.
5
Assessment of the drug metabolism capacity of the liver.肝脏药物代谢能力的评估。
Br J Clin Pharmacol. 1982 Nov;14(5):631-51. doi: 10.1111/j.1365-2125.1982.tb04950.x.
6
Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment.单次给药及长期治疗后磺吡酮及其主要代谢产物的药代动力学
Eur J Clin Pharmacol. 1985;28(1):97-103. doi: 10.1007/BF00635715.
7
Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.组胺H2受体拮抗剂的药代动力学和药效学特性。内在活性与有效血药浓度之间的关系。
Clin Pharmacokinet. 1991 Mar;20(3):218-36. doi: 10.2165/00003088-199120030-00004.