肝药物消除系统米氏常数的体内评估 - Suppr

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超能文献

In vivo evaluation of Michaelis-Menten constants of hepatic drug-eliminating systems.

作者信息

Pang K S, Rowland M, Tozer T N

出版信息

Drug Metab Dispos. 1978 Mar-Apr;6(2):197-200.

PMID:26537

Abstract

摘要

相似文献

In vivo evaluation of Michaelis-Menten constants of hepatic drug-eliminating systems.肝药物消除系统米氏常数的体内评估

Drug Metab Dispos. 1978 Mar-Apr;6(2):197-200.

Clearance and biologic half-life as indices of intrinsic hepatic metabolism.清除率和生物半衰期作为肝脏内在代谢的指标。

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Physiologic pharmacokinetic models: relevance, experience, and future trends.生理药代动力学模型：相关性、经验及未来趋势。

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[Changes in drug kinetics in liver diseases and their importance in rational pharmacotherapy].[肝脏疾病中药物动力学的变化及其在合理药物治疗中的重要性]

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First-pass effect: nonlinear concept comprising an explicit solution of integrated Michaelis-Menten equation.首过效应：非线性概念，包含米氏方程积分的显式解。

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Use of a programmable calculator to determine steady-state levels of drugs eliminated by parallel first-order and Michaelis-Menten kinetics.使用可编程计算器来确定通过平行一级动力学和米氏动力学消除的药物的稳态水平。

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Influence of administration route and blood sampling site on the area under the curve. Assessment of gut wall, liver, and lung metabolism from a physiological model.

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引用本文的文献

The potential of developing high hepatic clearance drugs via controlled release: Lessons from Kirchhoff's Laws.通过控制释放开发高肝清除药物的潜力：基尔霍夫定律的启示。

J Control Release. 2024 Sep;373:564-567. doi: 10.1016/j.jconrel.2024.07.040. Epub 2024 Jul 29.

Saturable kinetics of intravenous chlorothiazide in the rhesus monkey.恒河猴静脉注射氯噻嗪的饱和动力学

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On the identification of Michaelis-Menten elimination parameters from a single dose-response curve.关于从单剂量反应曲线识别米氏消除参数

J Pharmacokinet Biopharm. 1984 Apr;12(2):193-221. doi: 10.1007/BF01059278.

Prediction of metabolic drug interactions involving beta-adrenoceptor blocking drugs.涉及β-肾上腺素能受体阻断药物的代谢性药物相互作用预测

Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):3S-10S. doi: 10.1111/j.1365-2125.1984.tb02422.x.

Assessment of the drug metabolism capacity of the liver.肝脏药物代谢能力的评估。

Br J Clin Pharmacol. 1982 Nov;14(5):631-51. doi: 10.1111/j.1365-2125.1982.tb04950.x.

Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment.单次给药及长期治疗后磺吡酮及其主要代谢产物的药代动力学

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Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.组胺H2受体拮抗剂的药代动力学和药效学特性。内在活性与有效血药浓度之间的关系。

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