Klippert P J, Noordhoek J
Drug Metab Dispos. 1985 Jan-Feb;13(1):97-101.
The venous equilibrium model (or well-stirred model) is used to determine the area under the blood concentration vs. time curve of a metabolite formed from a precursor drug. It will be shown that the AUC of a metabolite will change according to the route of precursor drug administration(whether intraarterially, intravenously, via the portal vein, or orally) when the drug and/or metabolite is eliminated by more than one organ. Elimination includes hepatic and extrahepatic metabolism and renal excretion. The validity of the model is probed by using literature data for drug and metabolite areas. Finally, the use of metabolite areas for evaluating the complete/incomplete absorption or orally administered precursor drug is discussed.
静脉平衡模型（或充分搅拌模型）用于确定由前体药物形成的代谢物的血药浓度-时间曲线下面积。当药物和/或代谢物由不止一个器官消除时，将表明代谢物的AUC会根据前体药物的给药途径（无论是动脉内、静脉内、经门静脉还是口服）而变化。消除包括肝脏和肝外代谢以及肾脏排泄。通过使用药物和代谢物面积的文献数据来探究该模型的有效性。最后，讨论了使用代谢物面积来评估口服前体药物的完全/不完全吸收情况。
