Department of Clinical Pharmacy, University of Michigan College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
DeBartolo Family Personalized Medicine Institute, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, USA.
Clin Pharmacol Ther. 2016 Feb;99(2):143-6. doi: 10.1002/cpt.294. Epub 2015 Nov 25.
Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor.
肿瘤基因组分析通过鉴定特定致癌驱动因子和选择有效的靶向药物，正在改变癌症治疗方式。同时，患者基因组分析也正在跨治疗领域应用，为治疗安全性选择合适的药物和剂量提供信息。将患者基因组分析与肿瘤遗传预先检测相结合，将使肿瘤学家能够做出明智的治疗决策，为每位患者及其肿瘤选择合适的药物和剂量。
