Hansch C, Kim D, Leo A J, Novellino E, Silipo C, Vittoria A
Department of Chemistry, Pomona College, Claremont, California.
Crit Rev Toxicol. 1989;19(3):185-226. doi: 10.3109/10408448909037471.
Correlation equations between logP (P = octanol water partition coefficient) and the biological activity of alcohols has been derived for 101 examples on all sorts of systems, from simple proteins to whole animals. This provides an overview of the toxic nature of hydrophobic compounds which can be used as a basis for comparison of more complex chemicals. About 100 examples of the hydrophobic effects of chemicals, other than alcohols, to various living systems or their parts are presented for comparison. It is clear that hydrophobic xenobiotics are toxic to almost every form of life, including humans (or parts there of).
针对从简单蛋白质到整个动物的各类系统中的101个实例，推导了logP（P = 正辛醇 - 水分配系数）与醇类生物活性之间的相关方程。这提供了疏水化合物毒性本质的概述，可作为比较更复杂化学品的基础。还给出了约100个除醇类外化学品对各种生命系统或其部分的疏水效应实例以供比较。显然，疏水性外源性物质对几乎每种生命形式，包括人类（或其部分）都有毒性。
