Schardein J L, Keller K A
Reproductive and Developmental Toxicology Division, International Research and Development Corporation, Mattawan, Michigan.
Crit Rev Toxicol. 1989;19(3):251-339. doi: 10.3109/10408448909037473.
Some 50 chemicals have been identified from environmental, occupational, or therapeutic exposure data as being potential developmental toxicants in humans. The toxicity pattern of these chemicals in humans has been characterized and correlated with developmental toxicity end points in laboratory animal models in order to determine the relevance and predictiveness of the results of testing in animals in extrapolation to human data. In general, animal developmental toxicity data closely paralleled human outcomes, and while humans in most cases were more sensitive than animals, the data support the concept that, imperfections aside, studies in animals serve a vital role in the hazard identification process.
根据环境、职业或治疗性暴露数据，已确定约50种化学物质为人类潜在的发育毒物。这些化学物质对人类的毒性模式已得到表征，并与实验动物模型中的发育毒性终点相关联，以确定动物试验结果在推断人类数据时的相关性和预测性。一般来说，动物发育毒性数据与人类结果密切平行，虽然在大多数情况下人类比动物更敏感，但这些数据支持这样一种观点，即尽管存在缺陷，但动物研究在危害识别过程中起着至关重要的作用。
