Zaltas M M, Ahmed R, Foster C S
Hilles Immunology Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston.
Curr Eye Res. 1989 Feb;8(2):189-93. doi: 10.3109/02713688908995191.
HLA typing for A, B, and C locus antigens was performed on 70 patients with ocular cicatricial pemphigoid (OCP) and on 1849 controls. Additionally, typing for DR and DQ antigens and for the complement proteins (C2, factor B, C4A, and C4B) was performed on 63 patients and on the same control population. A significantly higher incidence of the following antigens was found in the OCP patients when compared to the control population: DR4 (43% in patients compared to 18% in controls, p = 0.0001); DR5 (41% compared to 16%, p = 0.0001); DQw3 (57% compared to 31%, p = 0.0010); A2 (60% compared to 28%, p = 0.0001); B8 (24% compared to 13%, p = 0.0086); B35 (19% compared to 9%, p = 0.0097); and B49 (7% compared to 2%, p = 0.0052). The complement types SC01, SC30, SC32, SC41, and SC42 were also significantly increased in patients compared to controls. No significant differences were found based on ethnic background, involvement of multiple mucous membranes, history of glaucoma, or deposition of specific immunoreactants in conjunctival biopsy samples. These findings may provide further insights into the pathogenesis of OCP and may help to localize a susceptibility gene for this autoimmune disease.
对70例瘢痕性类天疱疮（OCP）患者和1849名对照者进行了HLA A、B和C位点抗原分型。此外，还对63例患者和相同对照人群进行了DR和DQ抗原以及补体蛋白（C2、B因子、C4A和C4B）的分型。与对照人群相比，OCP患者中以下抗原的发生率显著更高：DR4（患者中为43%，对照者中为18%，p = 0.0001）；DR5（41% 对16%，p = 0.0001）；DQw3（57% 对31%，p = 0.0010）；A2（60% 对28%，p = 0.0001）；B8（24% 对13%，p = 0.0086）；B35（19% 对9%，p = 0.0097）；以及B49（7% 对2%，p = 0.0052）。与对照者相比，患者的补体类型SC01、SC30、SC32、SC41和SC42也显著增加。基于种族背景、多个粘膜受累情况、青光眼病史或结膜活检样本中特定免疫反应物的沉积情况，未发现显著差异。这些发现可能为OCP的发病机制提供进一步的见解，并可能有助于定位这种自身免疫性疾病的易感基因。
