Biswas J, Mukesh B N, Narain S, Roy S, Madhavan H N
Medical and Vision Research Foundation, Chennai, India.
Int Ophthalmol. 1997;21(5):277-81. doi: 10.1023/a:1006011114199.
Eales' disease is a primary retinal perivasculitis of an undetermined etiology seen predominantly in the Indian subcontinent and rarely in the West. Strong HLA association has been proven in retinal vasculitis of Behcet's disease. HLA association of Eales' disease is unknown and therefore the present study was undertaken to determine the same. The frequency of 30 HLA antigens (9 HLA-A antigens, 10 HLA-B antigens, 3 HLA-C antigens, 7 HLA-DR antigens and 1 HLA-DQ antigen) was studied by standard micro-lymphocytotoxicity test in 57 patients with Eales' disease and 50 age and sex-matched normal persons as controls. Both the patients and controls underwent complete ocular and clinical examinations and laboratory investigations. Inflammatory diseases similar to Eales' disease were ruled out in the patients before they were enrolled. Statistically significant higher phenotype frequencies of HLA B5 (B51), DR1 and DR4 were observed among patients with Eales' disease as compared to controls. The gene frequency of HLA B5 (B51) in our group of patients and controls was comparable with other earlier studies in the Indian population. The finding of significant association of Eales' patients with positive disequilibrium ( ) haplotypes A3-B44 and A11-B12 may be related to the development of this disease. The presence of the above HLA antigens may be indicative of predisposition to Eales' disease.
伊尔斯病是一种病因不明的原发性视网膜血管周围炎，主要见于印度次大陆，在西方罕见。白塞病的视网膜血管炎已证实与HLA有很强的关联。伊尔斯病与HLA的关联尚不清楚，因此进行了本研究以确定这一点。通过标准微量淋巴细胞毒性试验，研究了57例伊尔斯病患者和50例年龄及性别匹配的正常对照者中30种HLA抗原（9种HLA - A抗原、10种HLA - B抗原、3种HLA - C抗原、7种HLA - DR抗原和1种HLA - DQ抗原）的频率。患者和对照者均接受了全面的眼部和临床检查以及实验室检查。在患者入选前排除了与伊尔斯病相似的炎症性疾病。与对照组相比，伊尔斯病患者中观察到HLA B5（B51）、DR1和DR4的表型频率在统计学上显著更高。我们的患者组和对照组中HLA B5（B51）的基因频率与印度人群的其他早期研究相当。伊尔斯病患者与阳性不平衡（ ）单倍型A3 - B44和A11 - B12存在显著关联这一发现可能与该疾病的发生有关。上述HLA抗原的存在可能表明易患伊尔斯病。
