de Pablo Alicia, Bogoi Roberta, Bejarano Irene, Toro Carlos, Valencia Eulalia, Moreno Victoria, Martín-Carbonero Luz, Gómez-Hernando César, Rodés Berta
1 Foundation for Biomedical Research, University Hospital La Paz , Madrid, Spain .
2 IdiPAZ , Madrid, Spain .
AIDS Res Hum Retroviruses. 2016 Mar;32(3):232-6. doi: 10.1089/AID.2015.0137. Epub 2015 Dec 2.
The p21/CDKN1A protein has been described in vitro as well as in a small subset of patients as a restriction factor for HIV infection. We evaluated p21/CDKN1A mRNA expression on CD4(+) T cells from HIV-infected individuals with two outcomes (18 elite controllers and 28 viremic progressors). Our results show broad interindividual variation in this factor, which is unrelated to the patient's phenotype. Considering the gene's genetic surroundings in chromosome 6, such as HLA genotype and single nucleotide polymorphisms (SNPs), there was a positive association with carrying HLA-B2705 alleles and the rs733590 SNP. Thus, this natural variation of p21/CDKN1A alone does not appear to be a prognostic indicator of effective viral control in vivo and other factors must be considered.
p21/CDKN1A蛋白在体外以及一小部分患者中被描述为HIV感染的限制因子。我们评估了来自两组HIV感染个体（18名精英控制者和28名病毒血症进展者）的CD4(+) T细胞上p21/CDKN1A mRNA的表达。我们的结果显示该因子存在广泛的个体间差异，这与患者的表型无关。考虑到该基因在6号染色体上的遗传环境，如HLA基因型和单核苷酸多态性（SNP），携带HLA - B2705等位基因和rs733590 SNP存在正相关。因此，单独的p21/CDKN1A这种自然变异似乎并不是体内有效病毒控制的预后指标，必须考虑其他因素。
