Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.
Curr HIV/AIDS Rep. 2023 Dec;20(6):419-427. doi: 10.1007/s11904-023-00684-8. Epub 2023 Nov 27.
This review aims to elucidate the multifaceted role of the tumor suppressor protein p53 in the context of HIV infection. We explore how p53, a pivotal regulator of cellular processes, interacts with various facets of the HIV life cycle. Understanding these interactions could provide valuable insights into potential therapeutic interventions and the broader implications of p53 in viral infections.
Recent research has unveiled a complex interplay between p53 and HIV. Several reports have highlighted the involvement of p53 in restricting the replication of HIV within both immune and nonimmune cells. Various mechanisms have been suggested to unveil how p53 enforces this restriction on HIV replication. However, HIV has developed strategies to manipulate p53, benefiting its replication and evading host defenses. In summary, p53 plays a multifaceted role in HIV infection, impacting viral replication and disease progression. Recent findings underscore the importance of understanding the intricate interactions between p53 and HIV for the development of innovative therapeutic approaches. Manipulating p53 pathways may offer potential avenues to suppress viral replication and ameliorate immune dysfunction, ultimately contributing to the management of HIV/AIDS. Further research is warranted to fully exploit the therapeutic potential of p53 in the context of HIV infection.
目的综述：本综述旨在阐明肿瘤抑制蛋白 p53 在 HIV 感染背景下的多方面作用。我们探讨了作为细胞过程关键调节因子的 p53 如何与 HIV 生命周期的各个方面相互作用。理解这些相互作用可以为潜在的治疗干预措施提供有价值的见解，并深入了解 p53 在病毒感染中的广泛影响。
最新发现：最近的研究揭示了 p53 与 HIV 之间的复杂相互作用。有几项报道强调了 p53 在限制 HIV 在免疫和非免疫细胞中的复制中的作用。已经提出了多种机制来揭示 p53 如何对 HIV 复制施加这种限制。然而，HIV 已经开发出操纵 p53 的策略，使其复制受益并逃避宿主防御。总之，p53 在 HIV 感染中发挥着多方面的作用，影响病毒复制和疾病进展。最近的发现强调了理解 p53 与 HIV 之间复杂相互作用的重要性，以开发创新的治疗方法。操纵 p53 途径可能为抑制病毒复制和改善免疫功能障碍提供潜在途径，最终有助于 HIV/AIDS 的管理。需要进一步的研究来充分利用 p53 在 HIV 感染背景下的治疗潜力。
