通过硫醇-烯化学与NCA聚合反应相结合制备的杂功能糖多肽。
Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization.
作者信息
Krannig Kai-Steffen, Schlaad Helmut
机构信息
Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424, Potsdam, Germany.
Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany.
出版信息
Methods Mol Biol. 2016;1367:61-7. doi: 10.1007/978-1-4939-3130-9_6.
Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.
糖多肽可通过糖基化氨基酸N-羧基酸酐（NCA）的聚合反应制备，也可通过多肽与合适官能团的聚合后官能化反应制备。在此，我们展示了一种原位官能化和烯丙基甘氨酸N-羧基酸酐一锅法（共）聚合的方法，该方法结合了自由基硫醇-烯光化学和亲核开环聚合技术，以生成结构明确的杂功能糖多肽。
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