State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Molecules. 2018 Mar 26;23(4):760. doi: 10.3390/molecules23040760.
Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid -carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of γ-benzyl-l-glutamate--carboxyanhydride (BLG-NCA) monomer, to produce poly(γ-benzyl-l-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications.
尽管取得了显著的进展，但在相对较短的聚合时间内，使用方便的催化剂，在温和的条件下，通过α-氨基酸-羧酸酐（NCAs）的可控开环聚合（ROP）来制备结构明确的多肽仍然具有挑战性。在此，探索了一种由醋酸锌和苯胺组成的易得的催化剂体系，以介导γ-苄基-l-谷氨酸-羧酸酐（BLG-NCA）单体的快速 ROP，以可控分子量和较窄的分散度生产聚（γ-苄基-l-谷氨酸酯）（PBLGs）。考虑到醋酸锌和具有不同官能团的广泛苯胺衍生物的协同作用对 BLG-NCA 的 ROP 具有很好的控制作用，该方法可能为快速生成端功能化 PBLG 和用于众多生物医学应用的嵌段共聚物提供了一个有用的平台。
