基于糖聚合物的蛋白聚糖模拟物对糖萼的重塑
Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics.
作者信息
Huang Mia L, Smith Raymond A A, Trieger Greg W, Godula Kamil
机构信息
Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, 0358, La Jolla, CA, 92093-0358, USA.
出版信息
Methods Mol Biol. 2016;1367:207-24. doi: 10.1007/978-1-4939-3130-9_17.
Abstract
The cellular glycocalyx controls many of the crucial signaling pathways involved in cellular development. Synthetic materials that can mimic the multivalency and three-dimensional architecture of native glycans serve as important tools for deciphering and exploiting the roles of these glycans. Here we describe a chemical approach for the engineering of growth-factor interactions at the surfaces of stem cells using synthetic glycomimetic materials, with an eye towards promoting their commitment towards specific cell lineages with therapeutic potential.
摘要
细胞糖萼控制着许多参与细胞发育的关键信号通路。能够模拟天然聚糖的多价性和三维结构的合成材料，是解读和利用这些聚糖作用的重要工具。在此，我们描述了一种化学方法，利用合成糖模拟物材料在干细胞表面构建生长因子相互作用，旨在促进干细胞定向分化为具有治疗潜力的特定细胞谱系。
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Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells.用蛋白聚糖模拟物进行糖萼重塑可促进胚胎干细胞的神经分化。
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