Bagga Deepika, Modi Shilpi, Poonia Mahesh, Kaur Prabhjot, Bhattacharya D, Garg M L, Khushu Subash, Singh Namita
NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Brig. SK Mazumdar Marg, Timarpur, Delhi, India.
Department of Psychiatry, Base Hospital, Delhi Cantt., India.
Alcohol. 2015 Nov;49(7):639-46. doi: 10.1016/j.alcohol.2015.07.002. Epub 2015 Aug 28.
Long-term heavy alcohol consumption has traditionally been associated with impaired cognitive abilities, such as deficits in abstract reasoning, problem solving, verbal fluency, memory, attention, and visuospatial processing. The present study aimed at exploring these neuropsychological deficits in alcohol-use disorders (AUD) in an Indian population using the Postgraduate Institute Battery of Brain Dysfunction (PGIBBD) and their possible correlation with alterations in T2 relaxation times (T2-RT), using whole-brain voxel-based relaxometry (VBR) and conventional region of interest (ROI) approach. Multi-echo T2 mapping sequence was performed on 25 subjects with AUD and 25 healthy controls matched for age, education, and socioeconomic status. Whole-brain T2-RT measurements were conducted using VBR and conventional ROI approach. The study was carried out on a 3T whole-body MR scanner. Post processing for VBR and ROI analysis was performed using SPM 8 software and vendor-provided software, respectively. A PGIBBD test battery was conducted on all subjects to assess their cognitive abilities, and the results were reported as raw scores. VBR and ROI results revealed that AUD subjects showed prolonged T2-RTs in cerebellum bilaterally, parahippocampal gyrus bilaterally, right anterior cingulate cortex, left superior temporal gyrus, left middle frontal gyrus, and left calcarine gyrus. A significant correlation was also observed between the neuropsychological test raw scores and alterations in T2-RT in AUD subjects. Our results are consistent with previous studies suggesting tissue disruption or gliosis or demyelination as a possible reason for prolonged T2-RTs. This damage to brain tissue, which is evident as prolonged T2-RT, could possibly be associated with impaired cognitive abilities noticeable in AUD subjects.
长期大量饮酒传统上一直与认知能力受损有关，比如抽象推理、问题解决、语言流畅性、记忆、注意力和视觉空间处理方面的缺陷。本研究旨在使用研究生脑功能障碍成套测验（PGIBBD），探索印度人群酒精使用障碍（AUD）中的这些神经心理学缺陷，以及使用基于体素的全脑弛豫测量法（VBR）和传统感兴趣区域（ROI）方法，研究它们与T2弛豫时间（T2-RT）改变的可能相关性。对25名患有AUD的受试者和25名年龄、教育程度及社会经济地位相匹配的健康对照者进行了多回波T2映射序列检查。使用VBR和传统ROI方法进行全脑T2-RT测量。该研究在一台3T全身磁共振成像扫描仪上进行。分别使用SPM 8软件和供应商提供的软件对VBR和ROI分析进行后处理。对所有受试者进行了PGIBBD测试组合以评估他们的认知能力，结果以原始分数报告。VBR和ROI结果显示，AUD受试者双侧小脑、双侧海马旁回、右侧前扣带回皮质、左侧颞上回、左侧额中回和左侧距状回的T2-RT延长。在AUD受试者中，神经心理学测试原始分数与T2-RT改变之间也观察到显著相关性。我们的结果与先前的研究一致，提示组织破坏、胶质增生或脱髓鞘可能是T2-RT延长的原因。这种在T2-RT延长中明显可见脑组织损伤，可能与AUD受试者中明显的认知能力受损有关。
