Liang Jun, Wang Fan, Wang Dandan, Zhang Huayong, Zhao Cheng, Wang Shiying, Sun Lingyun
Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China.
Stem Cell Res Ther. 2015 Nov 4;6:213. doi: 10.1186/s13287-015-0203-1.
Radiation myelitis is a rather rare but devastating complication following therapeutic irradiation to neoplasms when the spinal cord is included within the radiation field. Symptoms of radiation myelitis with the therapeutic doses of radiation commonly employed are usually delayed and most often appear about 6 to 24 months following irradiation. So far, no treatment has proved satisfactory.Transplantation of allogeneic mesenchymal stem cells has been a promising therapy strategy for many disorders in the central nervous system, such as multiple sclerosis, neuromyelitis optica, and autoimmune encephalomyelitis. The cell-base therapy has shown to act to limit inflammation of central nervous system, stimulate neurogenesis, protect axons and promote remyelination. But it has not been established as a therapeutic option for radiation myelitis.In this report, we describe the outcome of allogeneic umbilical cord-derived mesenchymal stem cell transplantation in a patient with laryngeal carcinoma who developed radiation-induced myelitis of his spinal cord with characteristic magnetic resonance imaging changes.
放射性脊髓炎是肿瘤治疗性放疗后一种相当罕见但极具破坏性的并发症，当脊髓被纳入放疗野时就会发生。使用常用治疗剂量放疗引发的放射性脊髓炎症状通常会延迟出现，最常见于放疗后6至24个月左右。到目前为止，尚无令人满意的治疗方法。同种异体间充质干细胞移植已成为治疗许多中枢神经系统疾病（如多发性硬化症、视神经脊髓炎和自身免疫性脑脊髓炎）的一种有前景的治疗策略。这种基于细胞的疗法已显示出具有限制中枢神经系统炎症、刺激神经发生、保护轴突和促进髓鞘再生的作用。但它尚未成为放射性脊髓炎的一种治疗选择。在本报告中，我们描述了一名喉癌患者接受同种异体脐带间充质干细胞移植的结果，该患者因放疗导致脊髓放射性脊髓炎，并伴有特征性的磁共振成像改变。
