Maublant J C, Sournac M, Aiache J M, Veyre A
Division of Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France.
Eur J Nucl Med. 1989;15(3):143-5. doi: 10.1007/BF00254627.
The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74 +/- 27 min vs 352 +/- 77 min, P less than 0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.
用闪烁扫描相机对6名受试者监测了标记有99mTc - 二乙三胺五乙酸（DTPA）的茶碱缓释制剂的体外和体内溶出情况。该研究在禁食条件下进行，并在摄入标准化餐食后重复进行。结果显示，胃内有食物时，片剂的食管十二指肠转运时间显著延长（74±27分钟对352±77分钟，P＜0.001），但并未改变茶碱的生物利用度。这项研究是闪烁扫描法在药代动力学中具有明确价值的又一实例。
