Robertson C S, Hardy J G
Department of Surgery, Queen's Medical Centre, Nottingham, UK.
J Pharm Pharmacol. 1988 Aug;40(8):595-6. doi: 10.1111/j.2042-7158.1988.tb05315.x.
Oesophageal transit has been studied in six asymptomatic subjects aged 29-80 years. Using gamma scintigraphy, the transit of a liquid and five small tablets was monitored in each subject. All the subjects exhibited normal liquid swallowing, with 50% oesophageal clearance times of less than 5 s. In three subjects all the tablets passed through the oesophagus within 6 s, but transit was prolonged in 60% of the swallows in the other subjects. Tablet hold up occurred more frequently in the elderly. An additional drink of water cleared all lodged tablets into the stomach. To minimize possible mucosal irritation, the taking of even small tablets should be followed by an additional drink of water.
