Kastis George A, Furenlid Lars R, Wilson Donald W, Peterson Todd E, Barber H Bradford, Barrett Harrison H
Department of Radiology, Division of Nuclear Medicine, University of Arizona, Tucson, AZ 85724 USA.
Department of Radiology, Division of Nuclear Medicine, University of Arizona, Tucson, AZ 85724 USA, and also with the Optical Sciences Center, University of Arizona, Tucson, AZ 85721 USA.
IEEE Trans Nucl Sci. 2004 Feb;51(1):63-67. doi: 10.1109/TNS.2004.823337.
We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64×64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.
我们已经开发了一种用于小动物成像应用的双模态CT/SPECT成像系统。X射线系统包括一个商用微焦点X射线管和一个基于电荷耦合器件（CCD）的X射线相机。X射线透射测量基于锥束几何结构进行。通过在CCD探测器前围绕垂直轴旋转动物来获取各个投影。使用有序子集期望最大化（OS-EM）重建算法进行重建后可获得高分辨率CT图像。SPECT系统采用了我们小组之前开发的紧凑型半导体相机模块。该模块垂直于X射线管/CCD组合安装。它由一个64×64像素化的碲锌镉探测器和平行孔钨准直器组成。视野为1平方英寸。通过在探测器前旋转动物来获取用于SPECT重建的平面投影。展示了体模和小鼠的伽马射线和X射线图像。讨论了合并解剖图像和功能图像的程序。
