Meng L J, Fu G
Department of Nuclear, Plasma and Radiological Engineering, University of Illinois-Urbana-Champaign, Urbana, IL 61801 USA.
IEEE Trans Nucl Sci. 2008 Oct;55(5):2508-2517. doi: 10.1109/TNS.2008.2004278. Epub 2008 Dec 4.
In this paper, we present an experimental and Monte Carlo investigation of the intrinsic spatial resolution that can be achieved with the intensified electron-multiplying charge-coupled device (I-EMCCD) gamma camera [1]-[4]. This detector has a very low readout noise, an ultra-high spatial resolution and a large active area of ~ 80 mm diameter, which is well-suited for small animal imaging applications. The intrinsic detector resolutions achieved with different scintillators and under different experimental conditions were compared. In this study, the simple centroiding method was compared with two model-fitting approaches for finding the locations of gamma ray interactions. The results from Monte Carlo simulation have demonstrated that with an appropriate detector configuration, it is possible to achieve an intrinsic resolution of ~ 30 µm FWHM for detecting 27-35 keV gamma rays. The I-EMCCD scintillation camera offers a promising candidate for future ultra-high resolution SPECT imaging applications.
在本文中，我们对采用增强型电子倍增电荷耦合器件（I-EMCCD）的γ相机所能实现的固有空间分辨率进行了实验研究和蒙特卡罗研究[1]-[4]。该探测器具有极低的读出噪声、超高的空间分辨率以及直径约80 mm的大有效面积，非常适合小动物成像应用。比较了使用不同闪烁体并在不同实验条件下获得的探测器固有分辨率。在本研究中，将简单的质心定位方法与两种用于确定γ射线相互作用位置的模型拟合方法进行了比较。蒙特卡罗模拟结果表明，通过适当的探测器配置，对于检测27 - 35 keV的γ射线，有可能实现约30 µm半高宽的固有分辨率。I-EMCCD闪烁相机为未来超高分辨率单光子发射计算机断层显像（SPECT）成像应用提供了一个有前景的候选方案。
