Geyer Holly L, Dueck Amylou C, Scherber Robyn M, Mesa Ruben A
Division of Hospital Internal Medicine, Mayo Clinic, Scottsdale, AZ 85054, USA.
Department of Statistics, Mayo Clinic, Scottsdale, AZ 85054, USA.
Mediators Inflamm. 2015;2015:284706. doi: 10.1155/2015/284706. Epub 2015 Oct 11.
Myeloproliferative neoplasms (essential thrombocythemia, ET; polycythemia vera, PV; myelofibrosis, MF) are monoclonal malignancies associated with genomic instability, dysregulated signaling pathways, and subsequent overproduction of inflammatory markers. Acknowledged for their debilitating symptom profiles, recent investigations have aimed to determine the identity of these markers, the upstream sources stimulating their development, their prevalence within the MPN population, and the role they play in symptom development. Creation of dedicated Patient Reported Outcome (PRO) tools, in combination with expanded access to cytokine analysis technology, has resulted in a surge of investigations evaluating the potential associations between symptoms and inflammation. Emerging data demonstrates clear relationships between individual MPN symptoms (fatigue, abdominal complaints, microvascular symptoms, and constitutional symptoms) and cytokines, particularly IL-1, IL-6, IL-8, and TNF-α. Information is also compiling on the role symptoms paradoxically play in the development of cytokines, as in the case of fatigue-driven sedentary lifestyles. In this paper, we explore the symptoms inherent to the MPN disorders and the potential role inflammation plays in their development.
骨髓增殖性肿瘤（原发性血小板增多症、真性红细胞增多症、骨髓纤维化）是与基因组不稳定、信号通路失调以及随后炎症标志物过度产生相关的单克隆恶性肿瘤。鉴于其令人衰弱的症状特征，最近的研究旨在确定这些标志物的身份、刺激其产生的上游来源、它们在骨髓增殖性肿瘤患者群体中的患病率，以及它们在症状发展中所起的作用。专门的患者报告结局（PRO）工具的创建，结合对细胞因子分析技术的更广泛应用，导致了大量评估症状与炎症之间潜在关联的研究。新出现的数据表明，个体骨髓增殖性肿瘤症状（疲劳、腹部不适、微血管症状和全身症状）与细胞因子，特别是白细胞介素-1、白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α之间存在明确的关系。关于症状在细胞因子产生过程中所起的矛盾作用的信息也在不断积累，例如疲劳导致的久坐生活方式。在本文中，我们探讨了骨髓增殖性肿瘤疾病固有的症状以及炎症在其发展中可能发挥的作用。
