Lee Sun Min, Cho Young Hye, Lee Sang Yeoup, Jeong Dong Wook, Cho A Ra, Jeon Jeong Suk, Park Eun-Ju, Kim Yun Jin, Lee Jeong Gyu, Yi Yu Hyeon, Tak Young Jin, Hwang Hye Rim, Lee Seung-Hun, Han Junehee
Department of Laboratory Medicine and Molecular Genetics and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
Mediators Inflamm. 2015;2015:524291. doi: 10.1155/2015/524291. Epub 2015 Oct 11.
The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.
本研究的目的是调查用于评估肥胖的多个身体测量参数，特别是腹部内脏脂肪面积，以及各种代谢参数，包括作为氧化应激标志物的丙二醛（MDA）。我们评估了73名无严重肥胖的无症状中年男性的各种肥胖测量指标，包括体重指数（BMI）、腰围（WC）、腹部矢状径、使用双能X线吸收法测量的脂肪百分比、内脏脂肪面积（VFA）、皮下脂肪面积、与代谢疾病相关的多种生物标志物以及尿MDA。我们研究了多种肥胖测量指标、代谢标志物与尿MDA水平之间的关系，并评估了VFA与尿MDA之间的关联。在内脏肥胖组中，γ-谷氨酰转移酶（GGT）、尿酸和尿MDA水平显著高于非内脏肥胖组（P = 0.008、P = 0.002和P = 0.018）。在肥胖测量指标中，尿MDA（r = 0.357，P = 0.002）和尿酸（r = 0.263，P = 0.027）水平仅与VFA显著正相关。即使在调整BMI和WC后，尿MDA、血清GGT和血清CRP仍与VFA显著正相关（分别为P = 0.001、P = 0.046和P = 0.023）。
