Liu Junfeng, Chen Dacan, Nie Golay D, Dai Zhenhua
Section of Immunology, Division of Dermatology, Second Affiliated Hospital, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou University of Chinese Medicine , Guangzhou , China.
School of Medicine, University of Texas Medical Branch (UTMB) , Galveston, TX , USA.
Front Immunol. 2015 Oct 19;6:494. doi: 10.3389/fimmu.2015.00494. eCollection 2015.
CD8(+)CD122(+) T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve counterparts. However, mounting evidence has demonstrated that murine CD8(+)CD122(+) T-cells exhibit a central memory phenotype (CD44(high)CD62L(high)), regulate T cell homeostasis, and act as regulatory T-cells (Treg) by suppressing both autoimmune and alloimmune responses. Importantly, naturally occurring murine CD8(+)CD122(+) Tregs are more potent in immunosuppression than their CD4(+)CD25(+) counterparts. They appear to be acting in an antigen-non-specific manner. Human CD8(+)CXCR3(+) T-cells are the equivalent of murine CD8(+)CD122(+) Tregs and also exhibit central memory phenotypes. In this mini-review article, we will summarize recent progresses in their phenotypes, homeostatic expansion, antigen-specificity, roles in the suppression of alloimmune and autoimmune responses, and the mechanisms underlying their inhibitory function.
传统上，CD8(+)CD122(+) T细胞被描述为抗原特异性记忆T细胞，与初始T细胞相比，它们对先前遇到的抗原反应更快、更强烈。然而，越来越多的证据表明，小鼠CD8(+)CD122(+) T细胞表现出中央记忆表型（CD44(高)CD62L(高)），调节T细胞稳态，并通过抑制自身免疫和同种免疫反应充当调节性T细胞（Treg）。重要的是，天然存在的小鼠CD8(+)CD122(+) Treg在免疫抑制方面比其CD4(+)CD25(+)对应物更有效。它们似乎以抗原非特异性方式发挥作用。人类CD8(+)CXCR3(+) T细胞等同于小鼠CD8(+)CD122(+) Treg，也表现出中央记忆表型。在这篇小型综述文章中，我们将总结它们在表型、稳态扩增、抗原特异性、在抑制同种免疫和自身免疫反应中的作用以及其抑制功能的潜在机制方面的最新进展。
