Hur Chae Wook, Choi Chang Hwa, Cha Seung Heon, Lee Tae Hong, Jeong Hae Woong, Lee Jae Il
Department of Neurosurgery, Medical Research Institute, Pusan National University School of Medicine, University Pusan National University Hospital, Busan, Korea.
Department of Diagnostic Radiology, Medical Research Institute, Pusan National University School of Medicine, University Pusan National University Hospital, Busan, Korea.
J Korean Neurosurg Soc. 2015 Sep;58(3):184-91. doi: 10.3340/jkns.2015.58.3.184. Epub 2015 Sep 30.
Anterior communicating artery (AcomA) aneurysms represent the most common intracranial aneurysms and challenging to treat due to complex vascularity. The purpose of this study was to report our experience of endovascular treatment of AcomA aneurysms.
Between January 2003 and December 2013, we retrospectively reviewed the medical records of 134 AcomA aneurysm patients available more than 6 months conventional angiographic and clinical follow-up results. We focused on aneurismal or AcomA vascular characters, angiographic and clinical follow-up results, and retreatment.
The rate of ruptured cases was 75.4%, and the small (<10 mm) aneurysms were 96.3%. Based on the subtypes defined by dominance of A1, 79 patients (59%) had contralateral A1 hypoplasia or agenesis. The immediate post-procedural angiography confirmed complete occlusion in 75.4%, partial occlusion in 24.6%. Procedure related complications were observed in 25 (18.6%) patients. Most of the adverse events were asymptomatic. Follow-up conventional angiography at ≥6 months was performed in all patients (mean 16.3 months) and major recanalization was noted in 6.7% and regrowth in one case. The aneurysm size (p=0.016), and initial treatment results (p=0.00) were statistically significant risk factors related to aneurysm recurrence. An overall improvement in mRS was observed during the clinical follow-up period and no rebleeding episode occurred.
This study demonstrated that endovascular treatment is an effective treatment modality for AcomA aneurysms with low morbidity. Patients should take long term clinical and angiographic follow-up in order to assess the recurrence and warrant retreatment, especially ruptured, large, and initially incomplete occluded aneurysms.
前交通动脉(AcomA)动脉瘤是最常见的颅内动脉瘤,因其血管结构复杂,治疗颇具挑战性。本研究旨在报告我们对AcomA动脉瘤进行血管内治疗的经验。
回顾性分析2003年1月至2013年12月期间134例AcomA动脉瘤患者的病历,这些患者均有超过6个月的传统血管造影和临床随访结果。我们重点关注动脉瘤或AcomA血管特征、血管造影和临床随访结果以及再次治疗情况。
破裂病例发生率为75.4%,小动脉瘤(<10 mm)占96.3%。根据A1优势型定义的亚型,79例(59%)患者存在对侧A1发育不全或缺失。术后即刻血管造影显示完全闭塞率为75.4%,部分闭塞率为24.6%。25例(18.6%)患者出现与手术相关的并发症。大多数不良事件无症状。所有患者均进行了≥6个月的随访传统血管造影(平均16.3个月),发现6.7%的患者有主要再通,1例有瘤体复发。动脉瘤大小(p=0.016)和初始治疗结果(p=0.00)是与动脉瘤复发相关的统计学显著危险因素。临床随访期间mRS总体改善,未发生再出血事件。
本研究表明,血管内治疗是治疗AcomA动脉瘤的一种有效治疗方式,发病率低。患者应进行长期的临床和血管造影随访,以评估复发情况并确定是否需要再次治疗,尤其是破裂、大型和初始闭塞不完全的动脉瘤。