Hussain Suleman S, Patel Darpan, Ghosh Rita, Kumar Addanki P
Department of Urology, The University of Texas Health Science Center, San Antonio, TX ; Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX.
Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, TX ; School of Medicine, Health Rest & Care System Management, School of Nursing, The University of Texas Health Science Center, San Antonio, TX.
Curr Pharmacol Rep. 2015 Dec 1;1(6):365-372. doi: 10.1007/s40495-015-0029-7. Epub 2015 Mar 21.
The current standard of care for prostate cancer includes hormone therapy, radiation therapy and radical prostatectomy, each with its own set of undesirable side effects. In this regard there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines we have found that Nexrutine, a dietary supplement derived from bark extract, has prostate cancer prevention activity. The "extract" nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine as a chemopreventive agent for prostate cancer management. The potential of Nexrutine was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore the focus of this review is on the use of Nexrutine in prostate cancer. In addition we have summarized the emerging evidence regarding the use of Nexrutine in other tumor models to demonstrate the potential benefits of Nexrutine.
目前前列腺癌的标准治疗方法包括激素疗法、放射疗法和根治性前列腺切除术，每种方法都有其自身一系列不良副作用。在这方面，迫切需要开发能够预防或延缓临床前列腺癌发展的策略。一个潜在领域涉及使用包括植物提取物在内的天然化合物。基于此，我们发现Nexrutine，一种源自树皮提取物的膳食补充剂，具有预防前列腺癌的活性。这种植物提取物由几种活性原小檗碱生物碱混合而成，使其能够同时针对前列腺癌中多个失调的信号通路。在这篇综述中，我们将强调Nexrutine作为前列腺癌化学预防剂在未来转化医学中的益处。Nexrutine的潜力最初被发现，随后针对前列腺癌进行了最为详尽的研究。因此，本综述的重点是Nexrutine在前列腺癌中的应用。此外，我们总结了关于Nexrutine在其他肿瘤模型中应用的新证据，以证明Nexrutine的潜在益处。
