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基于血管生成的鲁普提取物的抗增殖作用。

Antiproliferative Effect of Rupr. Based on Angiogenesis.

作者信息

Balážová Ľudmila, Kurhajec Slavomír, Kello Martin, Bedlovičová Zdenka, Zigová Martina, Petrovová Eva, Beňová Katarína, Mojžiš Ján, Eftimová Jarmila

机构信息

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in Košice, 041 81 Košice, Slovakia.

Department of Pharmacology, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 11 Košice, Slovakia.

出版信息

Life (Basel). 2022 May 21;12(5):767. doi: 10.3390/life12050767.

DOI:10.3390/life12050767
PMID:35629433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143060/
Abstract

Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was determined by irritation test in ovo. The potential cancerogenic effect was studied in vitro on a cellular level, in ovo by CAM assay and in vivo on whole organism . Extract from the bark of showed antiproliferative and antiangiogenic effects. The results of our work showed promising anticancer effects based also on the inhibition of angiogenesis with minimum negative effects.

摘要

刺黄柏是一种药用植物，因其具有积极的生物活性而被用于多种疾病的辅助治疗。本研究的目的是评估其主要代谢产物、应用安全性和抗癌潜力。通过高效液相色谱法测定小檗碱为主要生物碱。通过卵内刺激试验确定其有害特性。在细胞水平上进行体外研究、通过鸡胚绒毛尿囊膜试验在卵内进行研究以及在整个生物体上进行体内研究，以探讨其潜在的致癌作用。从[植物名称]树皮中提取的提取物显示出抗增殖和抗血管生成作用。我们的研究结果表明，基于对血管生成的抑制作用，其具有良好的抗癌效果，且负面影响最小。 （注：原文中“Extract from the bark of showed antiproliferative and antiangiogenic effects.”这里“of ”后面缺少植物名称，翻译时按有缺失信息处理了）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/8f582b931d90/life-12-00767-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/84b5d4d20a1a/life-12-00767-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/c8c56e02981b/life-12-00767-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/4b4952630ef9/life-12-00767-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/b53ba343b0b0/life-12-00767-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/a36edac88312/life-12-00767-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/70b70f4e7963/life-12-00767-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/eaead2002d3c/life-12-00767-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/d933a713a974/life-12-00767-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/8f582b931d90/life-12-00767-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/84b5d4d20a1a/life-12-00767-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/c8c56e02981b/life-12-00767-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/4b4952630ef9/life-12-00767-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/b53ba343b0b0/life-12-00767-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/a36edac88312/life-12-00767-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/70b70f4e7963/life-12-00767-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/eaead2002d3c/life-12-00767-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/d933a713a974/life-12-00767-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b43/9143060/8f582b931d90/life-12-00767-g009.jpg

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