• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

辛伐他汀通过诱导自噬对大鼠脊髓损伤的神经保护作用

Neuroprotective Effect of Simvastatin via Inducing the Autophagy on Spinal Cord Injury in the Rat Model.

作者信息

Gao Kai, Wang Guannan, Wang Yansong, Han Donghe, Bi Jing, Yuan Yajiang, Yao Tianchen, Wan Zhanghui, Li Haihong, Mei Xifan

机构信息

Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China.

College of Pharmacy, Liaoning Medical University, Jinzhou 121000, China.

出版信息

Biomed Res Int. 2015;2015:260161. doi: 10.1155/2015/260161. Epub 2015 Oct 11.

DOI:10.1155/2015/260161
PMID:26539474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4619759/
Abstract

Simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, is invariably used to treat cardiovascular diseases. Simvastatin has been recently demonstrated to have a neuroprotective effect in nervous system diseases. The present study aimed to further verify the neuroprotection and molecular mechanism of simvastatin on rats after spinal cord injury (SCI). The expression of Beclin-1 and LC3-B was evidently enhanced at postoperation days 3 and 5, respectively. However, the reduction of the mTOR protein and ribosomal protein S6 kinase p70 subtype (p70S6K) phosphorylation level occurred at the same time after SCI. Simvastatin significantly increased the expression of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). Meanwhile, immunofluorescence results indicated that the expression of chondroitin sulfate proteoglycan (CSPG) and caspase-3 protein was obviously reduced by simvastatin. Furthermore, Nissl staining and Basso, Beattie, and Bresnahan (BBB) scores showed that the quantity and function of motor neurons were visibly preserved by simvastatin after SCI. The findings of this study showed that simvastatin induced autophagy by inhibiting the mTOR signaling pathway and contributed to neuroprotection after SCI.

摘要

辛伐他汀是3-羟基-3-甲基戊二酰辅酶A还原酶的抑制剂，常用于治疗心血管疾病。最近已证明辛伐他汀在神经系统疾病中具有神经保护作用。本研究旨在进一步验证辛伐他汀对脊髓损伤（SCI）大鼠的神经保护作用及其分子机制。术后第3天和第5天，Beclin-1和LC3-B的表达分别明显增强。然而，SCI后同时出现mTOR蛋白和核糖体蛋白S6激酶p70亚型（p70S6K）磷酸化水平降低。辛伐他汀显著增加脑源性神经营养因子（BDNF）和胶质细胞源性神经营养因子（GDNF）的表达。同时，免疫荧光结果表明，辛伐他汀可明显降低硫酸软骨素蛋白聚糖（CSPG）和caspase-3蛋白的表达。此外，尼氏染色和Basso、Beattie和Bresnahan（BBB）评分显示，SCI后辛伐他汀可明显保留运动神经元的数量和功能。本研究结果表明，辛伐他汀通过抑制mTOR信号通路诱导自噬，并有助于SCI后的神经保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/0c8b9bc9d5f4/BMRI2015-260161.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/204cc7685fe0/BMRI2015-260161.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/7c828f69ab07/BMRI2015-260161.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/a5f135f070eb/BMRI2015-260161.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/5a0f07750fbc/BMRI2015-260161.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/e234436771f4/BMRI2015-260161.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/0c8b9bc9d5f4/BMRI2015-260161.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/204cc7685fe0/BMRI2015-260161.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/7c828f69ab07/BMRI2015-260161.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/a5f135f070eb/BMRI2015-260161.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/5a0f07750fbc/BMRI2015-260161.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/e234436771f4/BMRI2015-260161.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a596/4619759/0c8b9bc9d5f4/BMRI2015-260161.006.jpg

相似文献

1
Neuroprotective Effect of Simvastatin via Inducing the Autophagy on Spinal Cord Injury in the Rat Model.辛伐他汀通过诱导自噬对大鼠脊髓损伤的神经保护作用
Biomed Res Int. 2015;2015:260161. doi: 10.1155/2015/260161. Epub 2015 Oct 11.
2
Probucol inhibits neural cell apoptosis via inhibition of mTOR signaling pathway after spinal cord injury.普罗布考通过抑制脊髓损伤后mTOR信号通路来抑制神经细胞凋亡。
Neuroscience. 2016 Aug 4;329:193-200. doi: 10.1016/j.neuroscience.2016.05.019. Epub 2016 May 17.
3
Effect of pollen typhae on inhibiting autophagy in spinal cord injury of rats and its mechanisms.蒲黄对大鼠脊髓损伤自噬抑制作用及其机制
Int J Clin Exp Pathol. 2015 Mar 1;8(3):2375-83. eCollection 2015.
4
Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF.辛伐他汀治疗通过上调 BDNF 和 GDNF 的表达促进实验性脊髓损伤后的功能恢复。
Neurosci Lett. 2011 Jan 10;487(3):255-9. doi: 10.1016/j.neulet.2010.09.007. Epub 2010 Sep 19.
5
Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury.二甲双胍预处理通过增强自噬以及抑制脊髓损伤后的炎症和凋亡来提供神经保护作用。
Biochem Biophys Res Commun. 2016 Sep 2;477(4):534-540. doi: 10.1016/j.bbrc.2016.05.148. Epub 2016 May 28.
6
Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β-catenin signaling pathway after spinal cord injury.辛伐他汀通过激活脊髓损伤后Wnt/β-连环蛋白信号通路抑制神经细胞凋亡并促进运动功能恢复。
J Neurochem. 2016 Jul;138(1):139-49. doi: 10.1111/jnc.13382. Epub 2016 May 23.
7
Wnt-3a improves functional recovery through autophagy activation via inhibiting the mTOR signaling pathway after spinal cord injury.Wnt-3a 通过抑制脊髓损伤后的 mTOR 信号通路激活自噬来改善功能恢复。
Neurosci Lett. 2020 Oct 15;737:135305. doi: 10.1016/j.neulet.2020.135305. Epub 2020 Aug 17.
8
Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway.白藜芦醇通过激活自噬和抑制由SIRT1/AMPK信号通路介导的细胞凋亡来预防脊髓损伤。
Neuroscience. 2017 Apr 21;348:241-251. doi: 10.1016/j.neuroscience.2017.02.027. Epub 2017 Feb 24.
9
ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats.三磷酸腺苷（ATP）介导的蛋白激酶 B（Akt）/雷帕霉素靶蛋白（mTOR）/核糖体 S6 蛋白激酶（p70S6K）信号通路的激活促进大鼠脊髓损伤后运动功能的改善。
Neuroscience. 2010 Sep 1;169(3):1046-62. doi: 10.1016/j.neuroscience.2010.05.046. Epub 2010 Jun 1.
10
Exendin-4 Enhances Motor Function Recovery via Promotion of Autophagy and Inhibition of Neuronal Apoptosis After Spinal Cord Injury in Rats.Exendin-4 通过促进自噬和抑制脊髓损伤后神经元凋亡来增强大鼠的运动功能恢复。
Mol Neurobiol. 2016 Aug;53(6):4073-4082. doi: 10.1007/s12035-015-9327-7. Epub 2015 Jul 22.

引用本文的文献

1
Autophagy modulation attenuates sorafenib resistance in HCC induced in rats.自噬调节可减轻索拉非尼诱导的大鼠肝癌耐药性。
Cell Death Dis. 2024 Aug 16;15(8):595. doi: 10.1038/s41419-024-06955-5.
2
Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice.辛伐他汀可显著减轻未成年酒精诱导的心脏损伤。
Cardiovasc Toxicol. 2024 Jan;24(1):15-26. doi: 10.1007/s12012-023-09821-6. Epub 2024 Jan 23.
3
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy.脊髓损伤的靶向治疗：抑制细胞凋亡是一种很有前途的治疗策略。

本文引用的文献

1
Statins and the autonomic nervous system.他汀类药物与自主神经系统。
Clin Sci (Lond). 2014 Mar;126(6):401-15. doi: 10.1042/CS20130332.
2
Increased autophagy accelerates colchicine-induced muscle toxicity.自噬增强加速秋水仙碱诱导的肌肉毒性。
Autophagy. 2013 Dec;9(12):2115-25. doi: 10.4161/auto.26150.
3
Neuroprotective effects of perflurocarbon (oxycyte) after contusive spinal cord injury.全氟碳（氧细胞）对脊髓挫伤性损伤后的神经保护作用。
Mol Neurobiol. 2024 Jul;61(7):4222-4239. doi: 10.1007/s12035-023-03814-w. Epub 2023 Dec 8.
4
Simvastatin Induces Apoptosis And Suppresses Hepatocellular Carcinoma Induced In Rats.辛伐他汀诱导细胞凋亡并抑制大鼠肝癌的发生。
Appl Biochem Biotechnol. 2023 Mar;195(3):1656-1674. doi: 10.1007/s12010-022-04203-0. Epub 2022 Nov 11.
5
The role of Wnt/mTOR signaling in spinal cord injury.Wnt/mTOR信号通路在脊髓损伤中的作用。
J Clin Orthop Trauma. 2022 Jan 4;25:101760. doi: 10.1016/j.jcot.2022.101760. eCollection 2022 Feb.
6
Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling.辛伐他汀通过重塑脑脂类组学阻断雄性小鼠可卡因诱导的条件性位置偏爱复吸。
Neurosci Bull. 2021 Dec;37(12):1683-1702. doi: 10.1007/s12264-021-00771-z. Epub 2021 Sep 7.
7
Hypoxia inducible factor-1 (HIF-1α) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723.缺氧诱导因子-1（HIF-1α）通过 Circ 0001723 介导的 miR-380-3p/NLRP3 减少脊髓损伤中的炎症反应。
Biol Res. 2020 Aug 20;53(1):35. doi: 10.1186/s40659-020-00302-6.
8
Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury.抑制性 CSPG 与受体 PTPσ 的相互作用对自噬的调节及其对脊髓损伤后可塑性和再生的影响。
Exp Neurol. 2020 Jun;328:113276. doi: 10.1016/j.expneurol.2020.113276. Epub 2020 Mar 4.
9
Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications.他汀类药物对间充质干细胞生物学特性的影响及治疗意义。
Heart Fail Rev. 2021 Sep;26(5):1259-1272. doi: 10.1007/s10741-020-09929-9.
10
Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons.调节自噬在脊髓损伤中的治疗作用：直接和间接比较的网状Meta分析
Neural Regen Res. 2020 Jun;15(6):1120-1132. doi: 10.4103/1673-5374.270419.
J Neurotrauma. 2014 Feb 1;31(3):256-67. doi: 10.1089/neu.2013.3037. Epub 2013 Nov 21.
4
Autophagy reduces neuronal damage and promotes locomotor recovery via inhibition of apoptosis after spinal cord injury in rats.自噬通过抑制大鼠脊髓损伤后的细胞凋亡来减少神经元损伤并促进运动功能恢复。
Mol Neurobiol. 2014 Feb;49(1):276-87. doi: 10.1007/s12035-013-8518-3. Epub 2013 Aug 18.
5
Mitophagy is required for acute cardioprotection by simvastatin.线粒体自噬是辛伐他汀急性心脏保护作用所必需的。
Antioxid Redox Signal. 2014 Nov 10;21(14):1960-73. doi: 10.1089/ars.2013.5416. Epub 2013 Sep 20.
6
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.辛伐他汀通过抑制冠状动脉心肌细胞中的Rac1-mTOR信号通路增强自噬。
Cell Physiol Biochem. 2013;31(6):925-37. doi: 10.1159/000350111. Epub 2013 Jun 18.
7
Potential role of growth factors in the management of spinal cord injury.生长因子在脊髓损伤管理中的潜在作用。
World Neurosurg. 2015 Jan;83(1):120-31. doi: 10.1016/j.wneu.2013.01.042. Epub 2013 Jan 16.
8
Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α.辛伐他汀在脊髓创伤实验模型中的抗炎作用：涉及 PPAR-α。
J Neuroinflammation. 2012 Apr 26;9:81. doi: 10.1186/1742-2094-9-81.
9
Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection.雷帕霉素通过促进自噬、抗炎和神经保护作用对大鼠脊髓损伤后功能恢复的多方面影响。
J Surg Res. 2013 Jan;179(1):e203-10. doi: 10.1016/j.jss.2012.02.023. Epub 2012 Mar 30.
10
Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury.内源性和外源性褪黑素对脊髓损伤动物模型神经重建和功能恢复的有益作用。
J Pineal Res. 2012 Jan;52(1):107-19. doi: 10.1111/j.1600-079X.2011.00925.x. Epub 2011 Aug 19.