不同地理和种族文化区域轻度认知障碍的患病率：COSMIC合作研究
The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.
作者信息
Sachdev Perminder S, Lipnicki Darren M, Kochan Nicole A, Crawford John D, Thalamuthu Anbupalam, Andrews Gavin, Brayne Carol, Matthews Fiona E, Stephan Blossom C M, Lipton Richard B, Katz Mindy J, Ritchie Karen, Carrière Isabelle, Ancelin Marie-Laure, Lam Linda C W, Wong Candy H Y, Fung Ada W T, Guaita Antonio, Vaccaro Roberta, Davin Annalisa, Ganguli Mary, Dodge Hiroko, Hughes Tiffany, Anstey Kaarin J, Cherbuin Nicolas, Butterworth Peter, Ng Tze Pin, Gao Qi, Reppermund Simone, Brodaty Henry, Schupf Nicole, Manly Jennifer, Stern Yaakov, Lobo Antonio, Lopez-Anton Raúl, Santabárbara Javier
机构信息
Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia.
出版信息
PLoS One. 2015 Nov 5;10(11):e0142388. doi: 10.1371/journal.pone.0142388. eCollection 2015.
BACKGROUND
Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).
METHODS
Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.
RESULTS
The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).
CONCLUSION
Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.
背景
标准的变化、所研究人群的差异以及方法学的不同，导致对轻度认知障碍（MCI）的患病率估计范围广泛。
方法
将统一标准应用于来自美国、欧洲、亚洲和澳大利亚的11项研究的协调数据，并使用三种不同的认知障碍定义来确定MCI患病率估计值。
结果
已发表的MCI患病率估计范围为5.0%-36.7%。使用所有认知障碍定义后，该范围缩小：处于最低6.681%（3.2%-10.8%）的表现；临床痴呆评定量表评分为0.5（1.8%-14.9%）；简易精神状态检查表评分为24-27（2.1%-20.7%）。使用第一种定义的总体患病率为5.9%，且随年龄增加（P <.001），但不受性别或所调查的主要种族/族裔（白人和中国人）影响。未完成高中学业会增加患MCI的可能性（P≤.01）。
结论
将统一标准应用于协调数据大大减少了国际上MCI患病率的差异。
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