墨西哥裔美国人轻度认知障碍的风险因素。
Risk factors for mild cognitive impairment among Mexican Americans.
机构信息
Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA; Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA. Electronic address: Sid.O'
出版信息
Alzheimers Dement. 2013 Nov;9(6):622-631.e1. doi: 10.1016/j.jalz.2012.12.007. Epub 2013 May 2.
BACKGROUND
Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk for MCI among Mexican Americans.
METHODS
Data from 1628 participants (non-Hispanic n = 1002; Mexican American n = 626) were analyzed from two ongoing studies of cognitive aging and Alzheimer's disease, Project FRONTIER (Facing Rural Obstacles to health Now Through Intervention, Education & Research) and TARCC (Texas Alzheimer's Research & Care Consortium).
RESULTS
When looking at the full cohorts (non-Hispanic and Mexican American), age, education, Apolipoprotein E (APOE) ε4 status and gender were consistently related to MCI diagnosis across the two cohorts. However, when split by ethnicity, advancing age was the only significant risk factor for MCI among Mexican Americans across both cohorts.
CONCLUSIONS
The current data suggest that many of the previously established risk factors for MCI among non-Hispanic cohorts may not be predictive of MCI among Mexican Americans and point to the need for additional work aimed at understanding factors related to cognitive aging among this underserved segment of the population.
背景
尽管大量文献集中探讨了轻度认知障碍（MCI）的风险因素，但很少有出版物研究墨西哥裔美国人的 MCI 风险。
方法
对来自两个正在进行的认知老化和阿尔茨海默病研究（FRONTIER 项目和 TARCC）的 1628 名参与者（非西班牙裔 n = 1002；墨西哥裔美国人 n = 626）的数据进行了分析。
结果
在观察整个队列（非西班牙裔和墨西哥裔美国人）时，年龄、教育程度、载脂蛋白 E（APOE）ε4 状态和性别在两个队列中均与 MCI 诊断相关。然而，按族裔划分时，在两个队列中，年龄增长是墨西哥裔美国人 MCI 的唯一显著危险因素。
结论
目前的数据表明，许多先前在非西班牙裔人群中确定的 MCI 风险因素可能不能预测墨西哥裔美国人的 MCI，这表明需要进一步研究旨在了解该服务不足人群认知老化相关因素。
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