Sietsema W K
Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239.
Int J Clin Pharmacol Ther Toxicol. 1989 Apr;27(4):179-211.
Oral bioavailability is best defined as the rate and extent to which an active drug substance is absorbed and becomes available to the general circulation. This concept is discussed, along with several popular methods for determining absolute oral bioavailability. The absolute oral bioavailability of numerous drugs is reviewed and interspecies comparisons are made. In general, absolute oral bioavailability does not correlate well between species, though relative comparisons might be made.
口服生物利用度的最佳定义是活性药物被吸收并进入体循环的速度和程度。本文将讨论这一概念，以及几种常用的测定绝对口服生物利用度的方法。文中回顾了多种药物的绝对口服生物利用度，并进行了种间比较。一般来说，不同物种之间的绝对口服生物利用度相关性不佳，不过可以进行相对比较。
