Vekey K, Edwards D, Zerilli L F
Lepetit Research Centre, Gerenzano, Varese, Italy.
J Chromatogr. 1989 Mar 17;488(1):73-85. doi: 10.1016/s0378-4347(00)82940-0.
The advantages and technical problems related to the on-line connection of liquid chromatography and mass spectrometry are described, with special emphasis on applications in pharmaceutical chemistry. The most important characteristics of various interfaces, such as direct liquid introduction, Magic, continuous flow fast atom bombardment and thermospray, are discussed. Special applications to the study of thermally very labile compounds are considered.
描述了液相色谱与质谱联机的优点及相关技术问题，特别强调了在药物化学中的应用。讨论了各种接口的最重要特性，如直接液体引入、Magic、连续流快原子轰击和热喷雾。考虑了在热稳定性极差的化合物研究中的特殊应用。
