Manuck T A
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
BJOG. 2016 Feb;123(3):368-75. doi: 10.1111/1471-0528.13744. Epub 2015 Nov 6.
Pharmacogenomics and personalised medicine incorporate genetic factors, historical data, and environmental exposures to predict individual variation in response to medications. The study of pharmacology and pharmacogenomics is challenging in obstetrics, and our knowledge in this area lags behind other disciplines of medicine. Some preliminary data, however, suggest that some of the interindividual variation seen in response to medications given for the prevention (progesterone) and the treatment (nifedipine, terbutaline, and others) of preterm labour may be caused by pharmacogenomic effects. A comprehensive approach, integrating clinical data, environmental factors, including concomitant medications and genotype, to optimise the prevention and treatment strategies for preterm birth, is urgently needed.
Some of the variation to meds for prematurity prevention/treatment may arise from pharmacogenomic effects.
药物基因组学和个性化医疗纳入了遗传因素、历史数据以及环境暴露情况,以预测个体对药物反应的差异。药理学和药物基因组学的研究在产科领域具有挑战性,我们在这一领域的知识落后于医学的其他学科。然而,一些初步数据表明,在用于预防(孕酮)和治疗(硝苯地平、特布他林等)早产的药物反应中观察到的一些个体差异可能是由药物基因组学效应引起的。迫切需要一种综合方法,整合临床数据、环境因素(包括合并用药和基因型),以优化早产的预防和治疗策略。
早产预防/治疗药物的一些差异可能源于药物基因组学效应。