Youn In Kyung, Im Soo Ah, Lee Jae Wook, Chung Nak Gyun, Cho Bin
Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591 Republic of Korea.
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591 Republic of Korea.
Springerplus. 2015 Oct 6;4:577. doi: 10.1186/s40064-015-1380-1. eCollection 2015.
To find a relationship between clinical and sonographic appearance of hemorrhagic cystitis (HC) in pediatric hematooncology patients. Clinical and sonographic findings of 31 children (M:F = 18:13; mean age, 12.7 years) with HC in pediatric hematooncology patients were reviewed. For each patient, the onset of HC after transplantation, use of bladder-toxic agent, presence of BK viruria, and duration of disease were reviewed. Sonographic findings including bladder wall thickness (BWT), the type of bladder wall thickening (nodular vs. diffuse), occurrence of hydronephrosis or pyelonephritis were reviewed. We analyzed sonographic appearance and clinical manifestations of HC. HC occurred within 4 months after HSCT/BMT. 27 patients (87.0 %) were positive for BK viruria and 24 patients (77.4 %) took bladder-toxic agents. On sonography, nodular type bladder wall thickening was more frequent (54.8 %), and BWT was thicker in this group (p = 0.003). There was a positive correlation between the BWT on initial sonography and duration of cystitis (r (2) = 0.340). Hydronephrosis developed in 25.8 % of patients with HC, and as HC persisted longer, hydronephrosis occurred more (p = 0.004). In patients with HC after HSCT/BMT, the BWT on initial sonography correlates well with the duration of cystitis. And, longer time of HC develops the risk of hydronephrosis.
探寻小儿血液肿瘤学患者出血性膀胱炎（HC）的临床与超声表现之间的关系。回顾了31例小儿血液肿瘤学患者中HC患者（男∶女 = 18∶13；平均年龄12.7岁）的临床和超声检查结果。对每位患者，均回顾了移植后HC的发病情况、膀胱毒性药物的使用情况、BK病毒尿的存在情况以及疾病持续时间。回顾了超声检查结果，包括膀胱壁厚度（BWT）、膀胱壁增厚类型（结节状与弥漫性）、肾积水或肾盂肾炎的发生情况。我们分析了HC的超声表现和临床表现。HC发生于造血干细胞移植/骨髓移植后4个月内。27例患者（87.0%）BK病毒尿呈阳性，24例患者（77.4%）使用了膀胱毒性药物。超声检查显示，结节状膀胱壁增厚更为常见（54.8%），且该组的BWT更厚（p = 0.003）。初次超声检查时的BWT与膀胱炎持续时间之间存在正相关（r² = 0.340）。25.8%的HC患者发生了肾积水，且随着HC持续时间延长，肾积水的发生率更高（p = 0.004）。在造血干细胞移植/骨髓移植后发生HC的患者中，初次超声检查时的BWT与膀胱炎持续时间密切相关。而且，HC持续时间越长，发生肾积水的风险越高。
