Okuda Ryo, Matsushima Hidekazu, Aoshiba Kazutetsu, Oba Tomohiro, Kawabe Rie, Honda Koujiro, Amano Masako
Department of Respiratory Medicine, Saitama Red Cross Hospital, 8-3-33 Kami-ochiai, Chuo-ku, Saitama, 338-8553 Japan ; Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki Japan.
Department of Respiratory Medicine, Saitama Red Cross Hospital, 8-3-33 Kami-ochiai, Chuo-ku, Saitama, 338-8553 Japan.
Springerplus. 2015 Oct 31;4:657. doi: 10.1186/s40064-015-1455-z. eCollection 2015.
The levels of soluble intercellular adhesion molecule-1 (sICAM-1) have been reported to increase in patients with idiopathic pulmonary fibrosis. However, the utility of sICAM-1 has not been reported in detail. The aim of this study was to investigate whether sICAM-1 was a useful biomarker for stable idiopathic pulmonary fibrosis (IPF) and early phase of acute exacerbation of IPF. The patients who were diagnosed with IPF between 2013 and 2015 were enrolled. The levels of sICAM-1 and other interstitial pneumonia markers were measured. In this study, 30 patients with stable IPF and 11 patients with acute exacerbation of IPF were collected. Mean sICAM-1 levels were 434 ± 139 ng/mL for the stable phase of IPF, 645 ± 247 ng/mL for early phase of acute exacerbation of IPF, 534 ± 223 ng/mL for connective tissue disease-associated interstitial pneumonia, 221 ± 42 for chronic obstructive pulmonary disease, and 150 ± 32 ng/mL in healthy volunteers. For the stable phase of IPF, sICAM-1 levels correlated with Krebs von den Lungen-6 (KL-6) (r value: 0.41; p value: 0.036). Mean sICAM-1 levels were significantly higher in patients with early phase of acute exacerbation of IPF than with stable phase of IPF (p = 0.0199). Multiple logistic analyses indicated that the predictors for early phase of acute exacerbation of IPF were only sICAM-1 and C-reactive protein (odds ratio: 1.0093; 1.6069). In patients with stable IPF, sICAM-1 levels correlated with KL-6; sICAM-1 might be a predictive indicator for prognosis. In the early phase of acute exacerbation of IPF, sICAM-1 might be more useful for diagnosis than other interstitial pneumonia markers.
据报道，特发性肺纤维化患者的可溶性细胞间黏附分子-1（sICAM-1）水平会升高。然而，sICAM-1的效用尚未有详细报道。本研究的目的是调查sICAM-1是否是稳定期特发性肺纤维化（IPF）和IPF急性加重期早期的有用生物标志物。纳入了2013年至2015年期间被诊断为IPF的患者。测量了sICAM-1和其他间质性肺炎标志物的水平。本研究收集了30例稳定期IPF患者和11例IPF急性加重期患者。IPF稳定期的sICAM-1平均水平为434±139 ng/mL，IPF急性加重期早期为645±247 ng/mL，结缔组织病相关间质性肺炎为534±223 ng/mL，慢性阻塞性肺疾病为221±42，健康志愿者为150±32 ng/mL。对于IPF稳定期，sICAM-1水平与克雷伯斯-冯-登-卢肯斯-6（KL-6）相关（r值：0.41；p值：0.036）。IPF急性加重期早期患者的sICAM-1平均水平显著高于IPF稳定期患者（p = 0.0199）。多因素逻辑分析表明，IPF急性加重期早期的预测指标仅为sICAM-1和C反应蛋白（比值比：1.0093；1.6069）。在稳定期IPF患者中，sICAM-1水平与KL-6相关；sICAM-1可能是预后的预测指标。在IPF急性加重期早期，sICAM-1可能比其他间质性肺炎标志物对诊断更有用。
