Poole Kristie L, Schmidt Louis A, Missiuna Cheryl, Saigal Saroj, Boyle Michael H, Van Lieshout Ryan J
Department of Clinical Epidemiology and Biostatistics, McMaster University, Canada.
Department of Psychology, Neuroscience, & Behaviour, McMaster University, Canada.
J Affect Disord. 2016 Jan 15;190:294-299. doi: 10.1016/j.jad.2015.10.031. Epub 2015 Oct 28.
To determine if childhood motor coordination is associated with lifetime major depressive disorder (MDD), current generalized anxiety disorder (GAD), and attention-deficit/hyperactivity disorder (ADHD) in adulthood, and to examine if extremely low birth weight (ELBW; <1000 g) status moderates the strength of these associations.
Prospective study of a cohort of normal birth weight (NBW) controls and ELBW survivors. Participants completed the short form Bruininks-Oseretsky Test of Motor Proficiency (BOTMP-SF) at age 8. At age 29-36, participants completed the Mini International Neuropsychiatric Interview to diagnose the psychiatric disorders of interest.
Birth weight status significantly influenced the strength and direction of associations between childhood motor coordination and adult psychiatric outcomes such that the odds of MDD (Pinteraction=.02) and GAD (Pinteraction=.01) increased with worsening motor scores in NBW adults but not ELBW survivors. Stratified analyses indicated that in NBW adults, for each one-point decrease in BOTMP-SF score, the odds of lifetime MDD increased by 10% (OR=1.10, 95% CI: 1.01-1.20).
Participant attrition reduced sample size and that may have limited our ability to detect statistically significant results for some of our analyses.
Poorer motor coordination in early life has a negative long-term impact on the development of MDD and GAD of individuals born at NBW. The long-term mental health risks of childhood motor coordination problems are significant and highlight the importance of recognizing motor deficits in all children, so that associated psychological difficulties can be identified and treated at an early age.
确定儿童期运动协调性是否与成年期的终生重度抑郁症（MDD）、当前广泛性焦虑症（GAD）和注意力缺陷多动障碍（ADHD）相关，并检验极低出生体重（ELBW；<1000克）状态是否会调节这些关联的强度。
对一组正常出生体重（NBW）对照者和ELBW幸存者进行前瞻性研究。参与者在8岁时完成了简短版布鲁因inks -奥塞茨基运动技能测试（BOTMP - SF）。在29 - 36岁时，参与者完成了迷你国际神经精神病学访谈以诊断感兴趣的精神疾病。
出生体重状态显著影响儿童期运动协调性与成人精神疾病结局之间关联的强度和方向，使得NBW成年人中MDD（P交互作用 = 0.02）和GAD（P交互作用 = 0.01）的患病几率随运动评分变差而增加，但ELBW幸存者中并非如此。分层分析表明，在NBW成年人中，BOTMP - SF评分每降低1分，终生MDD的患病几率增加10%（OR = 1.10，95%CI：1.01 - 1.20）。
参与者流失减少了样本量，这可能限制了我们对某些分析检测统计学显著结果的能力。
生命早期较差的运动协调性对NBW出生个体的MDD和GAD发展具有负面长期影响。儿童期运动协调问题的长期心理健康风险显著，凸显了识别所有儿童运动缺陷的重要性，以便在早期识别并治疗相关心理困难。
