Huang Jing, Han Sha-sha, Qin Dan-dan, Wu Li-hua, Song Yan, Yu Feng, Wang Su-xia, Liu Gang, Zhao Ming-hui
Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.
Institute of Nephrology, Peking University, Beijing, 100034, PR China.
PLoS One. 2015 Nov 6;10(11):e0141547. doi: 10.1371/journal.pone.0141547. eCollection 2015.
The aim of this study was to evaluate renal arteriosclerotic lesions in patients with lupus nephritis and investigate their associations with clinical and pathological characteristics, especially cardio-vascular features.
A retrospective cohort study.
Seventy-nine patients with renal biopsy-proven lupus nephritis, diagnosed between January 2000 and June 2008 from Peking University First Hospital.
In clinico-pathological data, patients with arteriosclerosis had higher ratio of hypertension and more severe renal injury indices compared with patients with no renal vascular lesions. More importantly, patients with renal arteriosclerosis had worse cardiac structure and function under transthoracic echocardiographic examination. Patients with renal arteriosclerosis tend to have higher ratios of combined endpoints compared with those of no renal vascular lesions, although the difference didn't reach statistical meanings (P = 0.104).
Renal arteriosclerotic lesion was common and associated with vascular immune complex deposits in lupus nephritis. It might have a certain degree of association with poor outcomes and cardiovascular events, which needs further explorations.
本研究旨在评估狼疮性肾炎患者的肾动脉硬化病变，并探讨其与临床及病理特征，尤其是心血管特征之间的关联。
一项回顾性队列研究。
79例经肾活检证实为狼疮性肾炎的患者，于2000年1月至2008年6月期间在北京大学第一医院确诊。
在临床病理数据方面，与无肾血管病变的患者相比，动脉硬化患者的高血压发生率更高，肾损伤指标更严重。更重要的是，经胸超声心动图检查显示，肾动脉硬化患者的心脏结构和功能更差。与无肾血管病变的患者相比，肾动脉硬化患者的复合终点发生率往往更高，尽管差异未达到统计学意义（P = 0.104）。
肾动脉硬化病变在狼疮性肾炎中常见，且与血管免疫复合物沉积有关。它可能与不良预后和心血管事件有一定程度的关联，这需要进一步探索。
