Do Michael, Byrne Linda K, Pearce Alan J
School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia; Cognitive Neuroscience Unit, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
J Neurosci Methods. 2016 Jan 30;258:24-7. doi: 10.1016/j.jneumeth.2015.10.013. Epub 2015 Nov 3.
Multi-site repetitive transcranial magnetic stimulation (rTMS) has been applied experimentally in the treatment of obsessive compulsive disorder (OCD).
This study was conducted to systematically evaluate the safety, tolerability and neurocognitive effects of rTMS applied to three cortical regions over a period of three months.
Twenty healthy participants aged 22-33 years were randomly allocated to receive one session of active or sham stimulation of low and high frequency rTMS applied sequentially to the pre-supplementary motor area, right-dorsolateral prefrontal cortex and left-orbitofrontal cortex totalling 9 min. Tolerability and safety was evaluated using a standardised safety questionnaire. Neurocognitive functioning was examined using the Cambridge Neuropsychological Test Automated Battery and measures of verbal fluency from the Delis-Kaplan Executive Functioning Test™ at five time points over three months.
The protocol was safe and tolerable. Frequencies of minor adverse effects were higher in active (17 endorsements) than sham (1 endorsement) conditions. No between group differences in neurocognitive functioning were identified over three months.
This study is the first to evaluate the feasibility of low and high frequency parameters applied sequentially in a single session to the three selected cortical regions whilst providing neurocognitive data.
rTMS applied sequentially over three cortical regions was found to be safe and tolerable in healthy individuals with no major neurocognitive effects over three months. Such findings can be used to inform the development of rTMS protocols involving multi-site stimulation for OCD.
多部位重复经颅磁刺激（rTMS）已在强迫症（OCD）治疗中进行了实验性应用。
本研究旨在系统评估在三个月期间对三个皮质区域施加rTMS的安全性、耐受性和神经认知效应。
20名年龄在22 - 33岁的健康参与者被随机分配，依次接受对辅助运动区、右侧背外侧前额叶皮质和左侧眶额叶皮质进行的低频和高频rTMS的一次主动或假刺激，每次刺激持续9分钟。使用标准化安全问卷评估耐受性和安全性。在三个月内的五个时间点，使用剑桥神经心理测试自动成套测验以及德利斯 - 卡普兰执行功能测验™中的语言流畅性测量来检查神经认知功能。
该方案是安全且可耐受的。主动刺激组（17项认可）的轻微不良反应发生率高于假刺激组（1项认可）。三个月内未发现组间神经认知功能存在差异。
本研究首次评估了在单次刺激中依次对三个选定皮质区域应用低频和高频参数的可行性，同时提供了神经认知数据。
发现在健康个体中，依次对三个皮质区域施加rTMS在三个月内是安全且可耐受的，未产生重大神经认知影响。这些发现可用于指导涉及多部位刺激治疗强迫症的rTMS方案的制定。
