ARC Centre of Excellence in Cognition and Its Disorders, Australia; Perception in Action Research Centre (PARC), Australia; Department of Cognitive Science, Australia.
ARC Centre of Excellence in Cognition and Its Disorders, Australia; Department of Cognitive Science, Australia.
Neuroimage. 2016 Jan 15;125:953-963. doi: 10.1016/j.neuroimage.2015.10.086. Epub 2015 Nov 3.
Stuttering is a disorder of speech affecting millions of people around the world. Whilst the exact aetiology of stuttering remains unknown, it has been hypothesised that it is a disorder of the neural mechanisms that support speech timing. In this article, we used magnetoencephalography (MEG) to examine activity from auditory regions of the brain in stuttering and non-stuttering children aged 3-9years. For typically developing children, we found that MEG oscillations in the beta band responded to rhythmic sounds with a peak near the time of stimulus onset. In contrast, stuttering children showed an opposite phase of beta band envelope, with a trough of activity at stimulus onset. These results suggest that stuttering may result from abnormalities in predictive brain responses which are reflected in abnormal entrainment of the beta band envelope to rhythmic sounds.
口吃是一种影响全球数百万人的言语障碍。虽然口吃的确切病因尚不清楚，但人们假设它是一种支持言语时间的神经机制障碍。在本文中，我们使用脑磁图（MEG）检查了 3-9 岁口吃和非口吃儿童大脑听觉区域的活动。对于正常发育的儿童，我们发现β频段的 MEG 振荡对节奏声音的反应在刺激开始时附近有一个峰值。相比之下，口吃儿童的β频带包络显示出相反的相位，在刺激开始时有一个活动的低谷。这些结果表明，口吃可能是由于预测性大脑反应异常引起的，这反映在β频带包络对节奏声音的异常同步上。
