Tang Feng, Tang Qingfa, Tian Yuanxin, Fan Qin, Huang Yao, Tan Xiaomei
School of Traditional Chinese Medical Sciences, Southern Medical University, 510515 Guangzhou, PR China; Guangdong Province Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, 510515 Guangzhou, PR China.
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
J Ethnopharmacol. 2015 Dec 24;176:402-12. doi: 10.1016/j.jep.2015.10.040. Epub 2015 Nov 3.
Certain herbal formulae from Traditional Chinese Medicine (TCM) are effective for treating and preventing diseases in clinical practice. Mahuang fuzi Xixin Decoction (MFXD) is a TCM that is used to treat allergic rhinitis (AR); however, the active ingredients and potential targets of its action against AR remain unclear. Therefore, further investigation is required.
A network pharmacology approach comprising drug-likeness evaluation, oral bioavailability prediction, multiple drug target prediction, and network analysis has been used in this study.
The comprehensive systematic approach was successfully to indentify 41 bioactive ingredients in MFXD, while 37 potential targets hit by these ingredients related to AR. Moreover, wherein four predicted ingredients possess anti-inflammatory effects were found by this technique.
Our works successfully predict the active ingredients and potential targets of MFXD for application to allergic rhinitis and helps to illustrate mechanism of action on a systematic level. This study not only provides new insights into the chemical basis and pharmacology of MFXD but also demonstrates a feasible method for discovering potential drugs from herbal medicine.
某些中药方剂在临床实践中对疾病的治疗和预防有效。麻黄附子细辛汤（MFXD）是一种用于治疗过敏性鼻炎（AR）的中药；然而，其针对AR的活性成分和潜在靶点仍不清楚。因此，需要进一步研究。
本研究采用了一种包括药物相似性评估、口服生物利用度预测、多药物靶点预测和网络分析的网络药理学方法。
该综合系统方法成功鉴定出MFXD中的41种生物活性成分，而这些成分作用于AR的37个潜在靶点。此外，通过该技术发现其中四种预测成分具有抗炎作用。
我们的工作成功预测了MFXD用于过敏性鼻炎的活性成分和潜在靶点，并有助于在系统层面阐明其作用机制。本研究不仅为MFXD的化学基础和药理学提供了新的见解，还展示了一种从草药中发现潜在药物的可行方法。
