Lasne C, Lowy R, Venegas W
Institut de Recherches Scientifiques sur le Cancer-CNRS, ER-304, Villejuif, France.
Mutagenesis. 1989 Jan;4(1):27-30. doi: 10.1093/mutage/4.1.27.
The induction of sister-chromatid exchanges (SCE) was studied in cultured human lymphocytes of two donors treated in G0 by five naphthofurans. The results showed that 2-nitro-7-methoxynaphtho(2,1-b)furan and 2-nitro-8-methoxy-naphtho(2,1-b)furan were very potent inducers of SCE, 2-nitronaphtho(2,1-b)furan was moderately active, while 2-nitro-7-bromonaphtho(2,1-b)furan and 7-methoxynaphtho(2,1-b)furan did not induce any SCE. These data corroborate the mutagenic, clastogenic and carcinogenic activities already evaluated in other in vitro and in vivo assays. They also show that some naphthofurans, but not all, are able to induce long-lived DNA lesions, like most alkylating agents.
研究了五种萘并呋喃对两名供体处于G0期的培养人淋巴细胞中姐妹染色单体交换（SCE）的诱导作用。结果表明，2-硝基-7-甲氧基萘并[2,1-b]呋喃和2-硝基-8-甲氧基萘并[2,1-b]呋喃是非常有效的SCE诱导剂，2-硝基萘并[2,1-b]呋喃活性中等，而2-硝基-7-溴萘并[2,1-b]呋喃和7-甲氧基萘并[2,1-b]呋喃未诱导出任何SCE。这些数据证实了已在其他体外和体内试验中评估的诱变、致断裂和致癌活性。它们还表明，一些萘并呋喃（但不是全部）能够诱导像大多数烷化剂一样的长寿命DNA损伤。
