砷在体外可提高人淋巴细胞中的姐妹染色单体交换（SCE）率。
Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro.
作者信息
Zanzoni F, Jung E G
出版信息
Arch Dermatol Res. 1980;267(1):91-5. doi: 10.1007/BF00416927.
PMID:7387181
Abstract
The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giesmsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10(-6) M and 2 x 10(-6) M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.
摘要
采用Hoechst-吉姆萨染色法测定正常人淋巴细胞中期的姐妹染色单体交换（SCE）数量。添加10⁻⁶M和2×10⁻⁶M的无机三价砷（Na₂HAsO₄）可诱导SCE显著且呈剂量依赖性增加。该现象与体外砷诱导染色体畸变的证据一样敏感。
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