Puig M, Carbonell E, Xamena N, Creus A, Marcos R
Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Spain.
Mutagenesis. 1989 Jan;4(1):72-4. doi: 10.1093/mutage/4.1.72.
Two pyrethroid insecticides, cypermethrin and fenvalerate, were tested for their ability to induce chromosome structural aberrations and sister chromatid exchanges in cultured human peripheral blood lymphocytes. Fenvalerate, but not cypermethrin, increased the frequencies of chromosome-type aberrations and sister chromatid exchanges. In addition, both pyrethroids affected the cell cycle causing a decrease in the proliferative rate index at concentrations greater than 10 micrograms/ml.
对两种拟除虫菊酯类杀虫剂氯氰菊酯和氰戊菊酯进行了测试，以研究它们在培养的人外周血淋巴细胞中诱导染色体结构畸变和姐妹染色单体交换的能力。氰戊菊酯而非氯氰菊酯增加了染色体型畸变和姐妹染色单体交换的频率。此外，两种拟除虫菊酯类杀虫剂均影响细胞周期，在浓度大于10微克/毫升时导致增殖率指数下降。
