Surrallés J, Carbonell E, Puig M, Xamena N, Creus A, Marcos R
Departament de Genética i de Microbiologia, Universitat Autónoma de Barcelona, Spain.
Toxicol Lett. 1990 Dec;54(2-3):151-5. doi: 10.1016/0378-4274(90)90178-o.
The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 micrograms/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.
