Rentero Redondo Lorena, Iniesta Navalón Carles, Gascón Cánovas Juan Jose, Tomás Jimenez Cristina, Sánchez Álvarez Carmen
Servicio de Farmacia Hospital General Universitario Reina Sofía, Murcia..
Departamento de Salud Pública Universidad de Medicina, Murcia..
Nutr Hosp. 2015 Nov 1;32(5):2169-77. doi: 10.3305/nh.2015.32.5.9712.
to determine the prevalence of malnutrition in patients aged 65 years or more at admission and factors associated with its presence. Analyze excess hospital stay (EHS), economic impact and premature readmission rate associated with hospital malnutrition in elderly patient.
retrospective study conducted at the University Hospital Reina Sofía. All patients aged 65 years or older admitted to internal medicine in 2011. The sample size was calculated taking into account the income of the previous year, and considering a prevalence of malnutrition of 50% with a 95% and included error of 5%. To define the degree of malnutrition nutritional control tool (CONUT), which establishes a score based on albumin, total cholesterol and lymphocyte determination was used. To determine the factors associated with the presence of moderate to severe malnutrition analysis of multivariate logistic regression was performed. For each patient the EHS, premature readmissions and the associated cost to EHS was calculated. A threshold of statistical significance of 0.05 was used for all analyzes and were performed with SPSS v15.0.
310 patients, of whom 54.2% were women were included, the mean age was 80.1 years (SD: 6.8), ranging between 65 and 95 years. Regarding diagnosis at admission 27.4% were respiratory diseases, 22.6% of the circulatory and digestive 11.6%. The median Charlson index was 2.0, found that 36.8% of patients had high comorbidity. The most prevalent chronic diseases were diabetes mellitus (44.2%), chronic kidney disease (25.2%) and dementia (10.6). Regarding the CONUT, 75.8% of patients met the criteria of malnutrition: 42.6% mild, 28.7% moderate and severe 4.5%, of which only 46.6% had some nutritional support during admission. Factors associated with the presence of moderate to severe malnutrition were female gender (OR: 1.7; 95%: 1.1 - 2.8), age over 80 years (OR: 2.0, IC 95%: 1.2 - 3.5), and dementia (OR: 2.4; IC 95%:1.2 - 5.2). No association with comorbidity or with other chronic diseases was found. Regarding the EHS (days) differences between patients with moderate to severe malnutrition (4.7; IC 95%: 2.3 - 7.1) and normally nourished (-0.1; IC 95%: -1.4 - 1.2) (p = 0.001) were found, but were not for cases of mild malnutrition (1.6, 95%: 0.5-2.8) (p = 0.07).Regarding the rate of premature readmission in malnourished patients was 28/235 (11.9%). The cost associated with EHS / 100 patients was € 195 479.4 for moderate malnutrition, mild malnutrition € 73 484.8, and normally nourished patients represented a saving of € 12 353.
hospital malnutrition in elderly patients remains an unsolved problem, given the high prevalence found, associated to an excess of hospital stay and increased hospital costs, especially in patients with moderate to severe malnutrition. The CONUT is a nutritional screening tool very useful for the speed and validity of their results, and allows detecting patients at risk or nutritional alert without lead to increased costs.
确定65岁及以上患者入院时营养不良的患病率及其相关因素。分析老年患者医院营养不良相关的住院时间延长(EHS)、经济影响和过早再入院率。
在雷纳索菲亚大学医院进行的回顾性研究。纳入2011年内科收治的所有65岁及以上患者。根据上一年的收入计算样本量,考虑营养不良患病率为50%,95%置信区间,误差为5%。使用营养控制工具(CONUT)定义营养不良程度,该工具基于白蛋白、总胆固醇和淋巴细胞测定建立评分。为确定与中度至重度营养不良存在相关的因素,进行多因素逻辑回归分析。计算每位患者的EHS、过早再入院情况以及EHS相关成本。所有分析采用0.05的统计学显著性阈值,并使用SPSS v15.0进行分析。
纳入310例患者,其中54.2%为女性,平均年龄80.1岁(标准差:6.8),年龄范围在65至95岁之间。入院诊断方面,27.4%为呼吸系统疾病,22.6%为循环系统疾病,11.6%为消化系统疾病。查尔森指数中位数为2.0,发现36.8%的患者合并症严重。最常见的慢性病为糖尿病(44.2%)、慢性肾病(25.2%)和痴呆(10.6%)。关于CONUT,75.8%的患者符合营养不良标准:42.6%为轻度,28.7%为中度,4.5%为重度,其中仅46.6%的患者在入院期间接受了某种营养支持。与中度至重度营养不良存在相关的因素为女性(比值比:1.7;95%置信区间:1.1 - 2.8)、80岁以上(比值比:2.0,95%置信区间:1.2 - 3.5)和痴呆(比值比:2.4;95%置信区间:1.2 - 5.2)。未发现与合并症或其他慢性病有关联。关于EHS(天数),发现中度至重度营养不良患者(4.7;95%置信区间:2.3 - 7.1)与营养正常患者(-0.1;95%置信区间:-1.4 - 1.2)之间存在差异(p = 0.001),但轻度营养不良患者(1.6,95%置信区间:0.5 - 2.8)无差异(p = 0.07)。营养不良患者的过早再入院率为28/235(11.9%)。中度营养不良患者EHS/100例患者的相关成本为195479.4欧元,轻度营养不良患者为73484.8欧元,营养正常患者节省12353欧元。
鉴于所发现的高患病率,老年患者医院营养不良仍是一个未解决的问题,与住院时间延长和医院成本增加相关,尤其是中度至重度营养不良患者。CONUT是一种营养筛查工具,因其结果的快速性和有效性非常有用,并且能够检测出有风险或营养警示的患者,而不会导致成本增加。