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[哥伦比亚大学不同海拔人群中血红蛋白浓度、血细胞比容和血氧饱和度的变化情况]

[BEHAVIOR OF HEMOGLOBIN CONCENTRATION, HEMATOCRIT AND OXYGEN SATURATION IN COLOMBIAN UNIVERSITY POPULATION AT DIFFERENT ALTITUDES].

作者信息

Trompetero González Andrea Catalina, Cristancho Mejía Edgar, Benavides Pinzón William Fernando, Serrato Roa Mauricio, Landinez Macias María Paula, Rojas Joel

机构信息

Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá..

Departamento de Biología, Universidad Nacional de Colombia, Bogotá..

出版信息

Nutr Hosp. 2015 Nov 1;32(5):2309-18. doi: 10.3305/nh.2015.32.5.9711.

Abstract

INTRODUCTION

the development of this research is base on the growing interest in understanding the adaptations to chronic hipoxia mainly in the range of intermediate altitudes (1 500-3 000 m.s.n.m) and the need to establish parameters of normality in the variables [Hb], Hct and SO2 for diagnostic and characterization of the population purposes.

OBJECTIVE

to analyze the behavior of the [Hb], Hct and SaO2 at different intermediate altitudes (970 m.s.n.m, 1 520 m.s.n.m, 1 728 m.s.n.m, 1 923 m.s.n.m, 2 180 m.s.n.m and 2 600 m.s.n.m) in order to contribute to the knowledge of the high altitude physiology and the clinical field to support the diagnosis of anemia.

METHODS

clinically healthy subjects with low levels of physical activity and food consumption report containing iron. Total of 264 participants of both genders between 18 and 30 years. The blood samples were collected from the antecubital vein and the earlobe and analyzed in a radiometer. A non-parametric statistical analysis was performed.

RESULTS

with increasing of altitude, [Hb] and Hct values were increased while the SO2 decreased. Men showed higher values than women in [Hb] and Hct, related to lower values of SO2 than women.

DISCUSSION

a threshold variable was not found, perhaps because of the small distance between the altitudes. The values reported were similar but not identical to other studies. This difference could be explained by genetic diversity among populations.

CONCLUSIONS

this study allows for the first values of characterization of the study population. All altitudes were above the cutoff for the diagnosis of anemia ([Hb] 12 g/dl).

摘要

引言

本研究的开展基于人们日益增长的兴趣,即主要在中等海拔范围(海拔1500 - 3000米)了解对慢性缺氧的适应情况,以及为诊断和描述人群特征建立变量[血红蛋白](Hb)、血细胞比容(Hct)和血氧饱和度(SO2)的正常参数的需求。

目的

分析不同中等海拔(海拔970米、1520米、1728米、1923米、2180米和2600米)下[Hb]、Hct和动脉血氧饱和度(SaO2)的变化情况,以增进对高原生理学和临床领域的了解,辅助贫血诊断。

方法

选取身体活动水平低且饮食含铁量低的临床健康受试者。共有264名年龄在18至30岁之间的男女参与者。从前臂静脉和耳垂采集血样,并在辐射计上进行分析。进行非参数统计分析。

结果

随着海拔升高,[Hb]和Hct值升高,而SO2降低。男性的[Hb]和Hct值高于女性,且SO2值低于女性。

讨论

未发现阈值变量,可能是因为海拔之间的距离较小。报告的值与其他研究相似但不完全相同。这种差异可能由人群间的遗传多样性解释。

结论

本研究得出了研究人群特征的首个数值。所有海拔均高于贫血诊断临界值([Hb] 12 g/dl)。

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