Philandrianos C, Kerfant N, Jaloux C, Martinet L, Bertrand B, Casanova D
Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France.
Service de chirurgie plastique, CHRU La Cavale Blanche, boulevard Tanguy-Prigent, 29609 Brest, France.
Ann Chir Plast Esthet. 2016 Apr;61(2):128-35. doi: 10.1016/j.anplas.2015.09.005. Epub 2015 Nov 3.
Keloid scars are a dysregulated response to cutaneous wound healing and are characterized by excessive deposition of collagen. Clinical and histological aspects are typical but they are often confused with hypertrophic scars. Principal pathogenesis is abnormal regulation of the collagen equilibrium because of TGFβ. In this first part, clinical characteristics, physiopathology and histology of keloid scars are explained.
瘢痕疙瘩是皮肤伤口愈合的一种失调反应，其特征是胶原蛋白过度沉积。临床和组织学方面具有典型性，但它们常与增生性瘢痕相混淆。主要发病机制是由于转化生长因子β导致胶原蛋白平衡的异常调节。在第一部分中，将对瘢痕疙瘩的临床特征、生理病理学和组织学进行解释。
