Garner Justin, George Peter M, Renzoni Elisabetta
Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, United Kingdom.
Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, United Kingdom; National Heart and Lung Institute, Imperial College London, United Kingdom.
Pulm Pharmacol Ther. 2015 Dec;35:122-8. doi: 10.1016/j.pupt.2015.10.009. Epub 2015 Nov 3.
Cough in the context of interstitial lung disease (ILD) has not been the focus of many studies. However, chronic cough has a major impact on quality of life in a significant proportion of patients with ILD. For the purpose of this review, we have chosen to highlight some of the more frequently encountered diffuse lung diseases including idiopathic pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis and systemic sclerosis associated ILD. Many of the underlying mechanisms remain speculative and further research is now required to elucidate the complex pathways involved in the pathogenesis of chronic cough in ILD. This will hopefully pave the way for the identification of new therapeutic agents to alleviate this distressing and often intractable symptom.
间质性肺疾病（ILD）中的咳嗽尚未成为众多研究的焦点。然而，慢性咳嗽对相当一部分ILD患者的生活质量有重大影响。出于本综述的目的，我们选择重点介绍一些较常见的弥漫性肺疾病，包括特发性肺纤维化、结节病、过敏性肺炎以及与系统性硬化症相关的ILD。许多潜在机制仍属推测，目前需要进一步研究以阐明ILD中慢性咳嗽发病机制所涉及的复杂途径。这有望为识别新的治疗药物以缓解这种令人痛苦且往往难以治疗的症状铺平道路。
