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一项关于产后早期使用依托孕烯植入剂(Implanon®)及其对恶露持续时间影响的前瞻性队列研究。

A prospective cohort study of early postpartum etonogestrel implant (Implanon®) use and its effect on duration of lochia.

作者信息

Dobromilsky Kim C, Allen Penny L, Raymond Stephen H, Maindiratta Bhavna

机构信息

Accredited Registrar, Department of Obstetrics and Gynaecology, Royal Hobart Hospital, Hobart, Tasmania, Australia.

Research Fellow, Rural Clinical School, The University of Tasmania, Burnie, Tasmania, Australia.

出版信息

J Fam Plann Reprod Health Care. 2016 Jul;42(3):187-93. doi: 10.1136/jfprhc-2014-101081. Epub 2015 Nov 6.

Abstract

BACKGROUND

Etonogestrel (ENG) implants (Implanon(®)/Nexplanon(®)/Implanon NXT(®)) are employed as contraception in early postpartum patients. Follow-up is often not conducted by the hospital prescriber. Little is known about duration of lochia, in a modern setting, and even less is known about the effect of ENG implants on lochia.

AIMS

To determine if early postpartum (pre-discharge) insertion of Implanon for contraception was associated with a significant difference in duration of lochia. To record the number of patients who went on to have their Implanon removed during the study period and the reasons for removal.

METHODS

Prospective cohort study of 152 postpartum patients from a tertiary maternity unit in Hobart, Tasmania, Australia. The treatment group was women requesting Implanon prior to discharge. Controls were recruited from the same unit over the same time period, with the aim to match for birth weight and parity. Information was collected during face-to-face interviews or via telephone contact. Multivariate survival analysis was used to investigate lochia duration.

RESULTS

There were 73 controls and 79 women who had early postpartum Implanon inserted. Fourteen (17.7%) patients in the treatment group had their Implanon removed during the postpartum study period. In all of these cases the reason for removal was bleeding disturbance - prolonged or intermittent vaginal bleeding beyond 50 days postpartum. There was no significant difference in duration of lochia between the groups [median predicted duration 25 days (95% CI 22-27) in controls and 24 days (95% CI 21-26) in the treatment group].

CONCLUSIONS

Early postpartum insertion of Implanon for contraception was not associated with a statistically or clinically significant difference in duration of lochia.

摘要

背景

依托孕烯(ENG)植入剂(依伴侬(®)/尼爽(®)/依伴侬下一代(®))被用于产后早期患者的避孕。随访通常不由医院开处方者进行。在现代环境下,对于恶露持续时间了解甚少,而关于ENG植入剂对恶露的影响了解更少。

目的

确定产后早期(出院前)植入依伴侬进行避孕是否与恶露持续时间存在显著差异。记录在研究期间取出依伴侬的患者数量及取出原因。

方法

对来自澳大利亚塔斯马尼亚州霍巴特一家三级产科病房的152名产后患者进行前瞻性队列研究。治疗组为出院前要求植入依伴侬的女性。对照组在同一时期从同一病房招募,旨在匹配出生体重和产次。通过面对面访谈或电话联系收集信息。采用多变量生存分析来研究恶露持续时间。

结果

有73名对照组患者和79名产后早期植入依伴侬的女性。治疗组中有14名(17.7%)患者在产后研究期间取出了依伴侬。在所有这些病例中,取出的原因都是出血紊乱——产后50天以上持续或间歇性阴道出血。两组之间恶露持续时间无显著差异[对照组中位预测持续时间为25天(95%可信区间22 - 27),治疗组为24天(95%可信区间21 - 26)]。

结论

产后早期植入依伴侬进行避孕与恶露持续时间在统计学或临床上无显著差异。

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