Polakof S, Panserat S
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France.
INRA, UR1067 Nutrition Metabolism and Aquaculture, F-64310 Saint-Pée-sur-Nivelle, France.
Comp Biochem Physiol B Biochem Mol Biol. 2016 Sep;199:43-49. doi: 10.1016/j.cbpb.2015.11.001. Epub 2015 Nov 3.
Fifteen years ago, Tom Moon wrote a review on this journal in order to propose some explanations to the exacerbated glycaemic response after a glucose load or a carbohydrate meal intake observed in fish, the so-called intolerance to glucose. Before, but in most of cases after this paper, several laboratories worldwide started to make important efforts in order to better understand this strange phenotype observed in fish and that so far seemed to belong to diabetic humans only. Tom had been worked on fish metabolism for at least 30years when he proposed that mini-review and the paths opened by him in 2001 were followed by tens of fish researchers, making this paper a breaking point on the field. Fifteen years later, we propose not only to have a look to the answers given to the questions rose in that paper, but also to summarize how his career over all these years impacted the domain of glucose metabolism in fish. In the review, we will show how Tom Moon analysed at different levels (from genes up to the whole organism), using distinct experimental tools (cells, hormone or glucose injection, pumps, drugs) the questions of glucose metabolism, tolerance and nutrition in fish species.
十五年前，汤姆·穆恩在本期刊上发表了一篇综述，旨在对鱼类摄入葡萄糖负荷或碳水化合物餐后出现的血糖反应加剧现象（即所谓的葡萄糖不耐受）提出一些解释。在此之前，但在这篇论文发表后的大多数情况下，全球多个实验室开始做出重要努力，以更好地理解在鱼类中观察到的这种奇怪表型，而这种表型迄今为止似乎仅见于糖尿病患者。汤姆在提出那篇综述时，已经从事鱼类代谢研究至少30年了，2001年他开辟的研究路径被数十位鱼类研究人员所追随，使这篇论文成为该领域的一个转折点。十五年后，我们不仅提议回顾一下对该论文中提出的问题所给出的答案，还提议总结他这些年来的职业生涯如何影响了鱼类葡萄糖代谢领域。在这篇综述中，我们将展示汤姆·穆恩如何运用不同的实验工具（细胞、激素或葡萄糖注射、泵、药物），从不同层面（从基因到整个生物体）分析鱼类的葡萄糖代谢、耐受性和营养问题。
